Background: The only conclusive way to diagnose Alzheimer’s is to carry out brain autopsy
of the patient’s brain tissue and ascertain whether the subject had Alzheimer’s or any other …

Cytokines are low-molecular-weight mediators of cellular communication produced by multiple
cell types in the liver, with the Kupffer cell critically important. Inflammatory cytokines such …

Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
and its potential as a serious environmental health threat is beginning to be recognized. …

Using known occurrences of species and correlational modeling approaches has become a
common paradigm in broad-scale ecology and biogeography, yet important aspects of the …

The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide,
reaching near fixation in a matter of months. Here we show that D614G was more infectious …

Background Entrectinib is a potent inhibitor of tropomyosin receptor kinase (TRK) A, B, and
C, which has been shown to have anti-tumour activity against NTRK gene fusion-positive …

Background Adagrasib, an oral small-molecule inhibitor of mutant KRAS G12C protein, has
shown clinical activity in pretreated patients with several tumor types, including colorectal …

Correlational models of species’ ecological niches are commonly used to transfer model
rules onto other sets of conditions to evaluate species’ distributional potential. As with any …

Background Covalent Bruton's tyrosine kinase (BTK) inhibitors are efficacious in multiple B-cell
malignancies, but patients discontinue these agents due to resistance and intolerance. …

Background Ecological niche modeling is a set of analytical tools with applications in diverse
disciplines, yet creating these models rigorously is now a challenging task. The calibration …