Glucocorticoids serve as key stress response hormones that facilitate stress coping. However,
sustained glucocorticoid exposure is associated with adverse consequences on the brain, …

An emerging hypothesis suggests that the pathogenesis and treatment of depression is
likely to involve a plasticity of neuronal pathways. The inability of neuronal systems to exhibit …

Recent studies have begun to examine the influence of electroconvulsive shock (ECS) on
the expression of growth factors in brain, as well as alterations in the function and structure of …

The influence of 5-HT receptor agonists on the expression of BDNF in brain was determined.
Administration of a hallucinogenic 5-HT 2A /2C receptor agonist, but not a 5-HT 1A receptor …

Stress, which can precipitate and exacerbate depression, causes atrophy and in severe
cases death of hippocampal neurons. Atrophy of the hippocampus has also been observed in …

Antidepressants are known to increase brain derived neurotrophic factor (BDNF) mRNA in
the adult rat brain. The BDNF gene has four differentially regulated promoters that generate …

We have examined the influence of thyroid hormone on adult hippocampal neurogenesis,
which encompasses the proliferation, survival and differentiation of dentate granule cell …

The dentate gyrus region retains the ability to generate neurons throughout adulthood. A few
studies have examined the neurotransmitter regulation of adult hippocampal neurogenesis …

BACKGROUND: Adult-onset stressors exert opposing effects on hippocampal neurogenesis
and cognition, with enhancement observed following mild stress and dysfunction following …

Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in the hippocampal
damage observed in depression. BDNF has a complex gene structure with four 5′ …