[HTML][HTML] The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction

V Kalienkova, VC Mosina, C Paulino - Journal of Molecular Biology, 2021 - Elsevier
The TMEM16 family of membrane proteins displays a remarkable functional dichotomy –
while some family members function as Ca 2+ -activated anion channels, the majority of …

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F

C Alvadia, NK Lim, V Clerico Mosina, GT Oostergetel… - Elife, 2019 - elifesciences.org
10.7554/eLife.44365.001 The lipid scramblase TMEM16F initiates blood coagulation by
catalyzing the exposure of phosphatidylserine in platelets. The protein is part of a family of …

Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

V Kalienkova, V Clerico Mosina, L Bryner… - Elife, 2019 - elifesciences.org
10.7554/eLife.44364.001 Scramblases catalyze the movement of lipids between both leaflets
of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed …

[HTML][HTML] Structural basis for the activation of the lipid scramblase TMEM16F

…, C Alvadia, MS Straub, V Clerico Mosina… - Nature …, 2022 - nature.com
TMEM16F, a member of the conserved TMEM16 family, plays a central role in the initiation
of blood coagulation and the fusion of trophoblasts. The protein mediates passive ion and …

Single-particle cryo-EM of membrane proteins in lipid nanodiscs

V Kalienkova, C Alvadia, V Clerico Mosina… - … , and Structural Biology …, 2020 - Springer
Single-particle cryo-electron microscopy has become an indispensable technique in structural
biology. In particular when studying membrane proteins, it allows the use of membrane-…

[HTML][HTML] Consenso sobre el tratamiento del síndrome inflamatorio multisistémico asociado a COVID-19

…, RM Flores, CI Crowe, P Clerico Mosina… - Arch. argent …, 2021 - pesquisa.bvsalud.org
La pandemia ocasionada por el nuevo coronavirus (SARS-CoV-2), declarada por la
Organización Mundial de la Salud OMS) en marzo de 2020, afecta a un reducido número de …

Cryo-EM structures and functional characterization of the lipid scramblase TMEM16F

C Alvadia, NK Lim, VC Mosina, GT Oostergetel… - BioRxiv, 2018 - biorxiv.org
The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of
phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which …

[HTML][HTML] 12P KBA1413, an antibody derived from a cured AML patient, recognizes a unique CD43 glycoform shared by AML, MDS and solid cancer cells

VC Mosina, M Kedde, B Pieters, B Monica, K Maijoor… - ESMO Open, 2024 - esmoopen.com
Background The use of human B cells for antigen and antibody discovery is on the rise due
to the emergence of new techniques to tap into the human antigen-experienced B cell …

[PDF][PDF] Épulis congénito

…, P Brunacci, G Andrés, PC Mosina - Dermatol Pediatr …, 2009 - dermaya.com.mx
Congenital epulis or congenital granular cell tumor of the newborn is a congenital, benign in
nature and rare tumor of unknown etiology. It is a nodular lesion, measuring from 1 to 9 cm …

Investigating the mechanism of action of TMEM16 scramblases and FATP fatty acid transporters: connecting the dots between structure and function

VC Mosina - 2021 - research.rug.nl
As membrane transporters play an essential role in cellular functions by moving endogenous
compounds within and between cells, defective transport processes have been associated …