Neutrophil gelatinase‐associated lipocalin (NGAL), a 25 kDa protein produced by injured
nephron epithelia, is one of the most promising new markers of renal epithelial injury. In …

NGAL is rapidly and massively induced in renal epithelial injury and NGAL: siderophore:
iron complexes may comprise a physiological renoprotective mechanism. The data have …

Kidney damage induces the expression of a myriad of proteins in the serum and in the urine.
The function of these proteins in the sequence of damage and repair is now being studied …

An assay has been developed that allows the identification of molecules that function as type
I IFN antagonists. Using this assay, we have identified an Ebola virus-encoded inhibitor of …

The Ebola virus VP35 protein was previously found to act as an interferon (IFN) antagonist
which could complement growth of influenza delNS1 virus, a mutant influenza virus lacking …

Many proteins have been proposed to act as surrogate markers of organ damage, yet for
many candidates the essential biomarker characteristics that link the protein to the injured …

Background Infection with the Ebola virus induces overexpression of the procoagulant
tissue factor in primate monocytes and macrophages, suggesting that inhibition of the tissue-…

Ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15) reversibly conjugate to
proteins and mediate important innate antiviral responses. The ovarian tumor (OTU) domain …

The signaling network downstream of the ErbB family of receptors has been extensively
targeted by cancer therapeutics; however, understanding the relative importance of the different …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput
screening (HTS), but the complexity of organoid cultures poses a significant …