Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide
association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
[HTML][HTML] Association analyses identify 31 new risk loci for colorectal cancer susceptibility
…, J Fernandez-Tajes, S Farrington, V Svinti… - Nature …, 2019 - nature.com
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
Prediction of colorectal cancer risk based on profiling with common genetic variants
Increasing numbers of common genetic variants associated with colorectal cancer (CRC)
have been identified. Our study aimed to determine whether risk prediction based on common …
have been identified. Our study aimed to determine whether risk prediction based on common …
[HTML][HTML] Flexible and scalable diagnostic filtering of genomic variants using G2P with Ensembl VEP
…, M Halachev, W McLaren, DJ Moore, V Svinti… - Nature …, 2019 - nature.com
We aimed to develop an efficient, flexible and scalable approach to diagnostic genome-wide
sequence analysis of genetically heterogeneous clinical presentations. Here we present …
sequence analysis of genetically heterogeneous clinical presentations. Here we present …
Temporal-and strain-specific host microRNA molecular signatures associated with swine-origin H1N1 and avian-origin H7N7 influenza A virus infection
EK Loveday, V Svinti, S Diederich, J Pasick… - Journal of …, 2012 - Am Soc Microbiol
MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts,
acting as master regulators of cellular processes. Differential expression of miRNAs has …
acting as master regulators of cellular processes. Differential expression of miRNAs has …
[HTML][HTML] Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study
…, SM Farrington, P Vaughan-Shaw, V Svinti… - BMC medicine, 2018 - Springer
Background Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD)
levels are associated with higher risk of colorectal cancer (CRC), establishing …
levels are associated with higher risk of colorectal cancer (CRC), establishing …
Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas
…, M Timofeeva, W Chen, V Svinti… - International journal …, 2016 - academic.oup.com
Background: Low penetrance genetic variants, primarily single nucleotide polymorphisms,
have substantial influence on colorectal cancer (CRC) susceptibility. Most CRCs develop …
have substantial influence on colorectal cancer (CRC) susceptibility. Most CRCs develop …
Low plasma vitamin D is associated with adverse colorectal cancer survival after surgical resection, independent of systemic inflammatory response
…, LY Ooi, E Theodoratou, M Timofeeva, V Svinti… - Gut, 2020 - gut.bmj.com
Objective We assessed the effect of surgical resection of colorectal cancer (CRC) on
perioperative plasma vitamin D (25OHD) and C-reactive protein (CRP) level. We investigated the …
perioperative plasma vitamin D (25OHD) and C-reactive protein (CRP) level. We investigated the …
Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer
…, X Li, C Nyiraneza, X Ma, M Timofeeva, V Svinti… - Gut, 2020 - gut.bmj.com
Objective To provide an understanding of the role of common genetic variations in colorectal
cancer (CRC) risk, we report an updated field synopsis and comprehensive assessment of …
cancer (CRC) risk, we report an updated field synopsis and comprehensive assessment of …
Vitamin D treatment induces in vitro and ex vivo transcriptomic changes indicating anti-tumor effects
…, M Timofeeva, M Walker, V Svinti… - FASEB …, 2022 - portal.findresearcher.sdu.dk
Vitamin D deficiency is associated with risk of several common cancers, including colorectal
cancer (CRC). Here we have utilized patient derived epithelial organoids (ex vivo) and CRC …
cancer (CRC). Here we have utilized patient derived epithelial organoids (ex vivo) and CRC …