Cancer recurrence and metastasis, following successful treatment, constitutes a critical
threat in clinical oncology and are the leading causes of death amongst cancer patients. This …

Systemic and stem cell niche-emanating cytokines and growth factors can promote regeneration,
through mitosis. High mitosis, however, predisposes for all types of cancer and, thus, a …

The Drosophila trachea, as the functional equivalent of mammalian blood vessels, senses
hypoxia and oxygenates the body. Here, we show that the adult intestinal tracheae are …

The hypoxia-inducible factor-1α (HIF-1α) is an evolutionarily conserved transcription factor
with prominent roles in the hypoxic response, cell survival, angiogenesis and cancer. HIF-1α …

Since the molecular characterization of Drosophila midgut progenitors in 2006, a few
hundred articles studying fly intestinal stem cells have already been published. There was a …

Inflammatory signaling supports host defense against infection, not only through immune
cells, but also via regeneration of damaged tissue. Heightened regeneration, nevertheless, …

Chronic inflammation has been identified as an important risk factor for gastrointestinal
cancer. Nevertheless, the cellular events and the signaling pathways triggered by chronic …

The two Nobel prizes in physiology or medicine of 1995 and 2011 establish Drosophila genetics
as a significant contributor of genes and signaling pathways relevant to human disease, …

… Both studies found that HIF-1α/Sima expression was induced upon damage in TTCs,
whereas Tamamouna et al. noted an additional induction of HIF1α/Sima in the gut epithelium. …

Whole-body health relies on complex inter-organ signalling networks that enable organisms
to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine …