The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all
aspects of society, including mental health and physical health. We explore the psychological, …

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …

Microglia, the macrophages of the central nervous system parenchyma, have in the normal
healthy brain a distinct phenotype induced by molecules expressed on or secreted by …

One of the histological hallmarks of early multiple sclerosis lesions is primary demyelination,
with myelin destruction and relative sparing of axons. On the other hand, it is widely …

Microglia, the resident macrophages of the CNS, are exquisitely sensitive to brain injury and
disease, altering their morphology and phenotype to adopt a so-called activated state in …

We have examined the distribution of microglia in the normal adult mouse brain using
immunocytochemical detection of the macrophage specific plasma membrane glycoprotein F4/80. …

Microglia in the central nervous system are usually maintained in a quiescent state. When
activated, they can perform many diverse functions which may be either beneficial or harmful …

Background: Acute and chronic systemic inflammation are characterized by the systemic
production of the proinflammatory cytokine tumor necrosis factor α (TNF-α) that plays a role in …

Macrophages and microglia in the developing and adult mouse brain have been identified
by is consistent with the idea that dying neurons and axons provide a stimulus for …