User profiles for Vaisakh Puthusseryppady

Vaisakh Puthusseryppady

Postdoc, University of California (Irvine)
Verified email at uci.edu
Cited by 239

[HTML][HTML] Predicting real world spatial disorientation in Alzheimer's disease patients using virtual reality navigation tests

V Puthusseryppady, S Morrissey, H Spiers, M Patel… - Scientific Reports, 2022 - nature.com
Spatial navigation impairments in Alzheimer’s disease (AD) have been suggested to
underlie patients experiencing spatial disorientation. Though many studies have highlighted …

Functional connectivity between the entorhinal and posterior cingulate cortices underpins navigation discrepancies in at-risk Alzheimer's disease

G Coughlan, P Zhukovsky, V Puthusseryppady… - Neurobiology of …, 2020 - Elsevier
Navigation processes that are selectively mediated by functional activity in the entorhinal
cortex may be a marker of preclinical Alzheimer's disease (AD). Here, we tested if a short path …

[HTML][HTML] Spatial disorientation in Alzheimer's disease: the missing path from virtual reality to real world

V Puthusseryppady, L Emrich-Mills, E Lowry… - Frontiers in Aging …, 2020 - frontiersin.org
Spatial disorientation is one of the earliest symptoms in Alzheimer’s disease (AD)(Coughlan
et al., 2018), and has been increasingly measured using novel virtual reality (VR) …

[HTML][HTML] Cognitive and neuroimaging markers for preclinical vascular cognitive impairment

E Lowry, V Puthusseryppady, AK Johnen… - … -Cognition and Behavior, 2021 - Elsevier
Detection of incipient cognitive impairment and dementia pathophysiology is critical to identify
preclinical populations and target potentially disease modifying interventions towards them…

[HTML][HTML] Machine learning detects altered spatial navigation features in outdoor behaviour of Alzheimer's disease patients

A Ghosh, V Puthusseryppady, D Chan, C Mascolo… - Scientific Reports, 2022 - nature.com
Impairment of navigation is one of the earliest symptoms of Alzheimer’s disease (AD), but to
date studies have involved proxy tests of navigation rather than studies of real life behaviour. …

[HTML][HTML] Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease

G Coughlan, V Puthusseryppady, E Lowry, R Gillings… - PLoS …, 2020 - journals.plos.org
The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s
disease (AD). We aimed to determine their test-retest reliability in a preclinical AD …

Effectiveness of interventions for preventing people with dementia exiting or getting lost

L Emrich-Mills, V Puthusseryppady… - The …, 2021 - academic.oup.com
Background and Objectives People with dementia are at risk of exiting premises unsupervised,
eloping, or getting lost, potentially leading to harmful or distressing consequences. This …

[HTML][HTML] Path integration changes as a cognitive marker for vascular cognitive impairment?—A pilot study

E Lowry, V Puthusseryppady, G Coughlan… - Frontiers in Human …, 2020 - frontiersin.org
Path integration spatial navigation processes are emerging as promising cognitive markers
for prodromal and clinical Alzheimer’s disease (AD). However, such path integration …

Spatial memory and hippocampal remapping: Who will age well?

V Puthusseryppady, D Cossio… - Proceedings of the …, 2024 - National Acad Sciences
The simple question of “where am I?” can have profoundly different answers depending on
one’s age, abilities, or cognitive impairments. In addition to being able to connect the current …

Functional connectivity between the entorhinal and posterior cingulate cortices associated with navigation impairment following path integration in at-genetic-risk …

G Coughlan, P Zhukovsky, V Puthusseryppady… - bioRxiv, 2019 - biorxiv.org
Navigation processes mediated selectively by the entorhinal cortex (EC) may be impaired in
individuals with suspected preclinical Alzheimer’s disease (AD), but the clinical utility of …