Outer membrane vesicles produced by pathogenic strains of Escherichia coli block autophagic flux and exacerbate inflammasome activation

…, R Planès, S Bagayoko, V Duplan-Eche… - Autophagy, 2022 - Taylor & Francis
Escherichia coli strains are responsible for a majority of human extra-intestinal infections,
resulting in huge direct medical and social costs. We had previously shown that HlyF encoded …

[HTML][HTML] LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity

…, D Guipouy, R Houmadi, V Duplan-Eche… - Nature …, 2024 - nature.com
T-cell cytotoxic function relies on the cooperation between the highly specific but poorly
adhesive T-cell receptor (TCR) and the integrin LFA-1. How LFA-1-mediated adhesion may …

Stochastic asymmetric repartition of lytic machinery in dividing CD8+ T cells generates heterogeneous killing behavior

…, R Jugele, S Müller, M Doineau, V Duplan-Eche… - Elife, 2021 - elifesciences.org
Cytotoxic immune cells are endowed with a high degree of heterogeneity in their lytic
function, but how this heterogeneity is generated is still an open question. We therefore …

A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage

…, N Rouquié, C Bories, S Mélique, V Duplan-Eche… - Elife, 2022 - elifesciences.org
The ability to proliferate is a common feature of most T-cell populations. However, proliferation
follows different cell-cycle dynamics and is coupled to different functional outcomes …

Type-3 Secretion System–induced pyroptosis protects Pseudomonas against cell-autonomous immunity

…, O Cunrath, RF Dreier, JC Santos, V Duplan-Eche… - BioRxiv, 2019 - biorxiv.org
Inflammasome-induced pyroptosis comprises a key cell-autonomous immune process against
intracellular bacteria, namely the generation of dying cell structures. These so-called pore-…

Organisation spatiale de LFA-1 à la synapse immunologique des lymphocytes T cytotoxiques: approches de microscopie de super-résolution

R Houmadi - 2017 - theses.hal.science
LFA-1 (Lymphocyte Function Associated antigen-1) est une intégrine centrale dans la
fonction cytotoxique des lymphocytes T CD8+ car elle permet la formation de la synapse …

High content cell imaging reveals actin cytoskeleton-mediated control of the immunological synapse

Y German - 2020 - theses.hal.science
Cytotoxic lymphocytes rely on actin cytoskeleton remodeling to achieve their function. In
particular cytotoxic T lymphocytes and NK cells assemble the immunological synapse (IS), a …

Cupriavidus taiwanensis Bacteroids in Mimosa pudica Indeterminate Nodules Are Not Terminally Differentiated

M Marchetti, O Catrice, J Batut… - Applied and …, 2011 - Am Soc Microbiol
… We thank Fatima-Ezzahra L'Faqihi-Olive and Valérie Duplan-Eche from the IFR150 cytometry
platform and Bruno Payré and Isabelle Fourquaux from the IFR-BMT CMEAB platform for …

[HTML][HTML] A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia

E Saland, H Boutzen, R Castellano, L Pouyet… - Blood cancer …, 2015 - nature.com
… We thank Valérie Duplan-Eche, Delphine Lestrade and Fatima L’Faqihi-Olive for technical
assistance at the flow cytometry core facility of INSERM UMR1043. FdT is a fellowship from …

CD 146 expression on mesenchymal stem cells is associated with their vascular smooth muscle commitment

N Espagnolle, F Guilloton… - Journal of cellular …, 2014 - Wiley Online Library
… –Université Toulouse III, France, and technical assistance by Fatima Ezzahra L'Faqihi-Olive
and Valérie Duplan-Eche. We thank Naïs Prade for her help in microarray analysis. …