[HTML][HTML] The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

…, Y Jiang, A Fähnrich, F Ott, V Sencio… - Nature …, 2021 - nature.com
Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause
neurological symptoms. Here we describe structural changes in cerebral small vessels of patients …

[HTML][HTML] The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes

V Sencio, MG Machado, F Trottein - Mucosal Immunology, 2021 - Elsevier
Bacteria that colonize the human gastrointestinal tract are essential for good health. The gut
microbiota has a critical role in pulmonary immunity and host's defense against viral …

[PDF][PDF] Gut dysbiosis during influenza contributes to pulmonary pneumococcal superinfection through altered short-chain fatty acid production

V Sencio, A Barthelemy, LP Tavares, MG Machado… - Cell reports, 2020 - cell.com
Secondary bacterial infections often complicate viral respiratory infections. We hypothesize
that perturbation of the gut microbiota during influenza A virus (IAV) infection might favor …

[HTML][HTML] A druggable copper-signalling pathway that drives inflammation

…, F Dingli, D Loew, S Baulande, S Durand, V Sencio… - Nature, 2023 - nature.com
Inflammation is a complex physiological process triggered in response to harmful stimuli 1 .
It involves cells of the immune system capable of clearing sources of injury and damaged …

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters

V Sencio, A Machelart, C Robil, N Benech… - Gut …, 2022 - Taylor & Francis
Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral
infections. We herein hypothesized that disruption of gut homeostasis during severe acute …

SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiota

…, P Maisonnasse, A Desmons, B Delache, V Sencio… - Gut …, 2021 - Taylor & Francis
The current pandemic of coronavirus disease (COVID) 2019 constitutes a global public
health issue. Regarding the emerging importance of the gut-lung axis in viral respiratory …

Influenza virus infection impairs the gut's barrier properties and favors secondary enteric bacterial infection through reduced production of short-chain fatty acids

V Sencio, A Gallerand, M Gomes Machado… - Infection and …, 2021 - Am Soc Microbiol
Along with respiratory tract disease per se, viral respiratory infections can also cause
extrapulmonary complications with a potentially critical impact on health. In the present study, we …

[HTML][HTML] Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis

…, EM Melo, L Deruyter, B Pourcet, V Sencio… - Frontiers in …, 2022 - frontiersin.org
Short-chain fatty acids (SCFAs) are metabolites produced mainly by the gut microbiota with
a known role in immune regulation. Acetate, the major SCFA, is described to disseminate to …

Short-chain fatty acids as a potential treatment for infections: a closer look at the lungs

MG Machado, V Sencio, F Trottein - Infection and immunity, 2021 - Am Soc Microbiol
Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via
the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a …

[HTML][HTML] Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues

…, D Dombrowicz, L Sedano, V Sencio… - Communications …, 2020 - nature.com
Like all obligate intracellular pathogens, influenza A virus (IAV) reprograms host cell’s
glucose and lipid metabolism to promote its own replication. However, the impact of influenza …