Tumours progress despite being infiltrated by tumour-specific effector T cells 1 . Tumours
contain areas of cellular necrosis, which are associated with poor survival in a variety of …

Streptococcus pneumoniae is a major cause of pneumonia and a leading cause of death
world-wide. Antibody-mediated immune responses can confer protection against repeated …

How the age‐associated decline of immune function leads to increased cancer incidence is
poorly understood. Here, we have characterised the cellular composition of the γδ T‐cell …

Background Cowden's syndrome is a rare, autosomal dominant disease caused by mutations
in the phosphoinositide 3-kinase and phosphatase and tensin homolog (PTEN) gene. It is …

Th17 cells are key drivers of autoimmune disease. However, the signaling pathways
regulating Th17 polarization are poorly understood. Hedgehog signaling regulates cell fate …

PI3Ks regulate diverse immune cell functions by transmitting intracellular signals from Ag,
costimulatory receptors, and cytokine receptors to control cell division, differentiation, survival, …

Background Cellfood™ (CF) is a nutritional supplement containing deuterium sulphate,
minerals, amino acids, and enzymes, with well documented antioxidant properties. Its organic …

BACKGROUND Mucosal repair is the goal of medical therapy in IBD. Prospective inception
cohort pediatric studies suggest that suppression of mitochondrial genes lead to unfavorable …

Cytotoxic CD8 + T lymphocytes (CTLs) are critical to the immune response against
intracellular pathogens and cancer and act by eliminating infected and malignant cells through …

T helper 17 (Th17) cells play a key role in barrier protection against fungal and bacterial
pathogens but are also pathological drivers of many inflammatory diseases. Although the …