Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies
synaptic plasticity and brain development. The fragile X mental retardation protein (FMRP) is …

Fragile X syndrome (FXS) results from the loss of the fragile X mental retardation protein (FMRP),
an RNA-binding protein that regulates a variety of cytoplasmic mRNAs. FMRP …

Memories are thought to be sparsely encoded in neuronal networks, but little is known
about why a given neuron is recruited or allocated to a particular memory trace. Previous …

Collections of cells called engrams are thought to represent memories. Although there has
been progress in identifying and manipulating single engrams, little is known about how …

Unraveling the mechanisms by which the molecular manipulation of genes of interest
enhances cognitive function is important to establish genetic therapies for cognitive disorders. …

BACKGROUND: Structural and functional neuroimaging studies suggest abnormal activity
in the striatum of patients with the fragile X syndrome (FXS), the most common form of …

The dentate gyrus (DG) is important for encoding contextual memories, but little is known about
how a population of DG neurons comes to encode and support a particular memory. One …

The formation of long-lasting memories requires coordinated changes in gene expression
and protein synthesis. Although many studies implicate DNA modifications (DNA methylation, …

Memory formation is thought to be mediated by dendritic-spine growth and restructuring.
Myocyte enhancer factor 2 (MEF2) restricts spine growth in vitro, suggesting that this …

The pruning of dendritic spines during development requires autophagy. This process is
facilitated by long-term depression (LTD)-like mechanisms, which has led to speculation that …