CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1
V Panzeri, M Pieraccioli, E Cesari… - Nucleic Acids …, 2023 - academic.oup.com
Transcription-associated cyclin-dependent kinases (CDKs) regulate the transcription cycle
through sequential phosphorylation of RNA polymerase II (RNAPII). Herein, we report that …
through sequential phosphorylation of RNA polymerase II (RNAPII). Herein, we report that …
The splicing factor PTBP1 promotes expression of oncogenic splice variants and predicts poor prognosis in patients with non–muscle-invasive bladder cancer
P Bielli, V Panzeri, R Lattanzio, S Mutascio… - Clinical Cancer …, 2018 - AACR
Purpose: Non–muscle-invasive bladder cancer (NMIBC) is a malignant disease characterized
by high heterogeneity, which corresponds to dysregulated gene expression and …
by high heterogeneity, which corresponds to dysregulated gene expression and …
c-MYC empowers transcription and productive splicing of the oncogenic splicing factor Sam68 in cancer
C Caggiano, M Pieraccioli, V Panzeri… - Nucleic acids …, 2019 - academic.oup.com
The splicing factor Sam68 is upregulated in many human cancers, including prostate cancer
(PCa) where it promotes cell proliferation and survival. Nevertheless, in spite of its frequent …
(PCa) where it promotes cell proliferation and survival. Nevertheless, in spite of its frequent …
[HTML][HTML] The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
…, M De Musso, F Delle Monache, V Panzeri… - Journal of Experimental …, 2021 - Springer
Background Triple-negative breast cancer (TNBC) is the most heterogeneous and malignant
subtype of breast cancer (BC). TNBC is defined by the absence of expression of estrogen, …
subtype of breast cancer (BC). TNBC is defined by the absence of expression of estrogen, …
[HTML][HTML] SEMA6C: a novel adhesion-independent FAK and YAP activator, required for cancer cell viability and growth
Transmembrane semaphorins are signaling molecules, controlling axonal wiring and embryo
development, which are increasingly implicated in human diseases. Semaphorin 6C (…
development, which are increasingly implicated in human diseases. Semaphorin 6C (…
The RNA‐binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinoma
V Panzeri, I Manni, A Capone, C Naro… - Molecular …, 2021 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer. Most patients
present with advanced disease at diagnosis, which only permits palliative chemotherapeutic …
present with advanced disease at diagnosis, which only permits palliative chemotherapeutic …
[HTML][HTML] Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells
I Passacantilli, V Panzeri, P Bielli, D Farini… - Cell Death & …, 2017 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis. The
standard chemotherapeutic drug, gemcitabine, does not offer significant improvements for …
standard chemotherapeutic drug, gemcitabine, does not offer significant improvements for …
[HTML][HTML] Functional interaction between the oncogenic kinase NEK2 and Sam68 promotes a splicing program involved in migration and invasion in triple-negative …
…, C Caggiano, M De Musso, V Panzeri… - Frontiers in …, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype.
Poor prognosis in TNBC is partly due to lack of efficacious targeted therapy and high …
Poor prognosis in TNBC is partly due to lack of efficacious targeted therapy and high …
[HTML][HTML] RNA extraction from endoscopic ultrasound-acquired tissue of pancreatic cancer is feasible and allows investigation of molecular features
L Archibugi, V Ruta, V Panzeri, M Redegalli… - Cells, 2020 - mdpi.com
Transcriptome analyses allow the distinguishing of pancreatic ductal adenocarcinoma (PDAC)
subtypes, exhibiting different prognoses and chemotherapy responses. However, RNA …
subtypes, exhibiting different prognoses and chemotherapy responses. However, RNA …
[HTML][HTML] A new Phe-free protein substitute engineered to allow a physiological absorption of free amino acids for phenylketonuria
N Giarratana, G Gallina, V Panzeri, A Frangi… - Journal of Inborn …, 2018 - SciELO Brasil
An innovative technology (Physiomimic Technology) has been applied to amino acids (AAs)
formulated for patients with phenylketonuria, with the objective of masking AA taste and …
formulated for patients with phenylketonuria, with the objective of masking AA taste and …