We investigated the pharmacokinetic properties of Δ 9 -tetrahydrocannabinol (Δ 9 -THC),
the main psychoactive constituent of cannabis, in adolescent and adult male mice. The drug …

Post-traumatic stress disorder (PTSD) leads to enhanced alcohol drinking and development
of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover …

Rationale The endocannabinoid neurotransmitter, anandamide, has been implicated in the
central modulation of stress responses. Previous animal experiments have shown that …

The endocannabinoid system is a key regulator of the response to psychological stress.
Inhibitors of monoacylglycerol lipase (MGL), the enzyme that deactivates the endocannabinoid 2…

Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share
dysregulated neuroimmune-related pathways. Here, we used our established rat model of …

Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as
cardiovascular diseases, obesity and Alzheimer’s disease. Nevertheless, the potential …

The conversion of lipolysis-derived fatty acids into ketone bodies (ketogenesis) is a crucial
metabolic adaptation to prolonged periods of food scarcity. The process occurs primarily in …

Sphingolipids have been implicated in age-related neurodegeneration. Previous studies
have reported elevated ceramide levels in the brain of old rodents, but a systematic …

PURPOSE A growing body of evidence has implicated the endocannabinoid (eCB) system
in the acute, chronic, and withdrawal effects of alcohol/ethanol on synaptic function. These …

Impairments in the function of the hypothalamic-pituitary-adrenal (HPA) axis and enhanced
glucocorticoid receptor (GR) activity in the central amygdala (CeA) are critical mechanisms in …