The exon junction complex (EJC) is a central effector of the fate of mRNAs, linking nuclear
processing to mRNA transport, translation and surveillance. However, little is known about its …

Natural killer (NK) cells play critical roles in protection against hematological malignancies
but can acquire a dysfunctional state, which limits antitumor immunity. However, the …

Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic
stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid …

PURPOSE Understanding the immunobiology of the 15% to 30% of patients with follicular
lymphoma (FL) who experience progression of disease within 24 months (POD24) remains a …

Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and
cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of …

Background Sequencing technologies have advanced to the point where it is possible to
generate high-accuracy, haplotype-resolved, chromosome-scale assemblies. Several long-…

Background The exon junction complex (EJC) is a dynamic multi-protein complex deposited
onto nuclear spliced mRNAs upstream of exon-exon junctions. The four core proteins, …

A number of genetic studies have identified rare protein-coding DNA variations associated
with autism spectrum disorder (ASD), a neurodevelopmental disorder with significant genetic …

XRCC4-like factor (XLF) functions in classical non-homologous end-joining (cNHEJ) but is
dispensable for the repair of DNA double-strand breaks (DSBs) generated during V(D)J …

The main carcinogen for keratinocyte skin cancers (KCs) such as basal and squamous cell
carcinomas is ultraviolet (UV) radiation. There is growing evidence that accumulation of …