User profiles for Valentino M. Gantz
Valentino M GantzUCSD Verified email at ucsd.edu Cited by 3345 |
Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi
VM Gantz, N Jasinskiene… - Proceedings of the …, 2015 - National Acad Sciences
Genetic engineering technologies can be used both to create transgenic mosquitoes carrying
antipathogen effector genes targeting human malaria parasites and to generate gene-…
antipathogen effector genes targeting human malaria parasites and to generate gene-…
The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations
VM Gantz, E Bier - Science, 2015 - science.org
An organism with a single recessive loss-of-function allele will typically have a wild-type
phenotype, whereas individuals homozygous for two copies of the allele will display a mutant …
phenotype, whereas individuals homozygous for two copies of the allele will display a mutant …
Safeguarding gene drive experiments in the laboratory
Gene drive systems promote the spread of genetic elements through populations by assuring
they are inherited more often than Mendelian segregation would predict (see the figure). …
they are inherited more often than Mendelian segregation would predict (see the figure). …
Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline
HA Grunwald, VM Gantz, G Poplawski, XRS Xu, E Bier… - Nature, 2019 - nature.com
A gene drive biases the transmission of one of the two copies of a gene such that it is inherited
more frequently than by random segregation. Highly efficient gene drive systems have …
more frequently than by random segregation. Highly efficient gene drive systems have …
[HTML][HTML] Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies include …
technologies for controlling vector-borne pathogen transmission. These technologies include …
The dawn of active genetics
VM Gantz, E Bier - Bioessays, 2016 - Wiley Online Library
On December 18, 2014, a yellow female fly quietly emerged from her pupal case. What
made her unique was that she had only one parent carrying a mutant allele of this classic …
made her unique was that she had only one parent carrying a mutant allele of this classic …
Core commitments for field trials of gene drive organisms
Gene drive organisms (GDOs), whose genomes have been genetically engineered to spread
a desired allele through a population, have the potential to transform the way societies …
a desired allele through a population, have the potential to transform the way societies …
Gene editing technologies and applications for insects
Highlights • CRISPR-based gene editing has revolutionized functional genomics of insects.
• Gene editing technologies are invaluable tools for advanced insect genome engineering …
• Gene editing technologies are invaluable tools for advanced insect genome engineering …
[HTML][HTML] CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus
…, PT Leftwich, L Alphey, VM Gantz - Nature …, 2023 - nature.com
Culex mosquitoes pose a significant public health threat as vectors for a variety of diseases
including West Nile virus and lymphatic filariasis, and transmit pathogens threatening …
including West Nile virus and lymphatic filariasis, and transmit pathogens threatening …
[PDF][PDF] Active genetic neutralizing elements for halting or deleting gene drives
CRISPR-Cas9-based gene drive systems possess the inherent capacity to spread progressively
throughout target populations. Here we describe two self-copying (or active) guide RNA-…
throughout target populations. Here we describe two self-copying (or active) guide RNA-…