User profiles for Valentino M. Gantz

Valentino M Gantz

UCSD
Verified email at ucsd.edu
Cited by 3345

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi

VM Gantz, N Jasinskiene… - Proceedings of the …, 2015 - National Acad Sciences
Genetic engineering technologies can be used both to create transgenic mosquitoes carrying
antipathogen effector genes targeting human malaria parasites and to generate gene-…

The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations

VM Gantz, E Bier - Science, 2015 - science.org
An organism with a single recessive loss-of-function allele will typically have a wild-type
phenotype, whereas individuals homozygous for two copies of the allele will display a mutant …

Safeguarding gene drive experiments in the laboratory

…, P Duchek, OR Edwards, KM Esvelt, VM Gantz… - Science, 2015 - science.org
Gene drive systems promote the spread of genetic elements through populations by assuring
they are inherited more often than Mendelian segregation would predict (see the figure). …

Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline

HA Grunwald, VM Gantz, G Poplawski, XRS Xu, E Bier… - Nature, 2019 - nature.com
A gene drive biases the transmission of one of the two copies of a gene such that it is inherited
more frequently than by random segregation. Highly efficient gene drive systems have …

[HTML][HTML] Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi

A Adolfi, VM Gantz, N Jasinskiene, HF Lee… - Nature …, 2020 - nature.com
Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies include …

The dawn of active genetics

VM Gantz, E Bier - Bioessays, 2016 - Wiley Online Library
On December 18, 2014, a yellow female fly quietly emerged from her pupal case. What
made her unique was that she had only one parent carrying a mutant allele of this classic …

Core commitments for field trials of gene drive organisms

…, K Esvelt, SW Evans, RM Friedman, VM Gantz… - Science, 2020 - science.org
Gene drive organisms (GDOs), whose genomes have been genetically engineered to spread
a desired allele through a population, have the potential to transform the way societies …

Gene editing technologies and applications for insects

VM Gantz, OS Akbari - Current opinion in insect science, 2018 - Elsevier
Highlights • CRISPR-based gene editing has revolutionized functional genomics of insects.
• Gene editing technologies are invaluable tools for advanced insect genome engineering …

[HTML][HTML] CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus

…, PT Leftwich, L Alphey, VM Gantz - Nature …, 2023 - nature.com
Culex mosquitoes pose a significant public health threat as vectors for a variety of diseases
including West Nile virus and lymphatic filariasis, and transmit pathogens threatening …

[PDF][PDF] Active genetic neutralizing elements for halting or deleting gene drives

XRS Xu, EA Bulger, VM Gantz, C Klanseck, SR Heimler… - Molecular cell, 2020 - cell.com
CRISPR-Cas9-based gene drive systems possess the inherent capacity to spread progressively
throughout target populations. Here we describe two self-copying (or active) guide RNA-…