Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury to …

Although neurons within the peripheral nervous system (PNS) have a remarkable ability to
repair themselves after injury, neurons within the central nervous system (CNS) do not …

Neurons transmit long-range biochemical signals between cell bodies and distant axonal
sites or termini. To test the hypothesis that signaling molecules are hitchhikers on axonal …

We report that lipids contribute to regulate the bidirectional motility of late endocytic
compartments. Late endocytic vesicles loaded with cholesterol lose their dynamic properties, and …

Loss of FMRP causes fragile X syndrome (FXS), but the physiological functions of FMRP
remain highly debatable. Here we show that FMRP regulates neurotransmitter release in CA3 …

Here we demonstrate that the dual leucine zipper kinase (DLK) promotes robust regeneration
of peripheral axons after nerve injury in mice. Peripheral axon regeneration is accelerated …

Reactivation of a silent transcriptional program is a critical step in successful axon
regeneration following injury. Yet how such a program is unlocked after injury remains largely …

Early endocytic membrane traffic is regulated by the small GTPase Rab5, which cycles between
GTP- and GDP-bound states as well as between membrane and cytosol. The latter cycle …

Unlike neurons in the central nervous system (CNS), injured neurons in the peripheral
nervous system (PNS) can regenerate their axons and reinnervate their targets. However, …

Axon regeneration is an essential process to rebuild functional connections between injured
neurons and their targets. Regenerative axonal growth requires alterations in axonal …