MicroRNAs (miRNAs) are short RNA gene regulators typically produced from primary
transcripts that are cleaved by the nuclear microprocessor complex, with the resulting precursor …

Cellular transitions occur at all stages of organismal life from conception to adult regeneration.
Changing cellular state involves three main features: activating gene expression …

RNA folding plays a crucial role in RNA function. However, knowledge of the global
structure of the transcriptome is limited to cellular systems at steady state, thus hindering the …

MicroRNA (miRNA) maturation is regulated by interaction of particular miRNA precursors
with specific RNA-binding proteins. Following their biogenesis, mature miRNAs are …

How satellite cells and their progenitors balance differentiation and self-renewal to achieve
sustainable tissue regeneration is not well understood. A major roadblock to understanding …

Posttranscriptional regulation plays a crucial role in shaping gene expression. During the
maternal-to-zygotic transition (MZT), thousands of maternal transcripts are regulated. However, …

Gene expression is extensively regulated at the levels of mRNA stability, localization and
translation. However, decoding functional RNA-regulatory features remains a limitation to …

Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward
flow, which is sensed by cells at the left LRO margin. Ciliary activity of the calcium channel …

Post-transcriptional mRNA regulation shapes gene expression, yet how cis-elements and
mRNA translation interface to regulate mRNA stability is poorly understood. We find that the …

RNA folding plays a crucial role in RNA function. However, our knowledge of the global structure
of the transcriptome is limited to steady-state conditions, hindering our understanding of …