AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
…, JM Merchut-Maya, CJ Daniel, M Carinci, V Cesarini… - Nature, 2021 - nature.com
Mammalian development, adult tissue homeostasis and the avoidance of severe diseases
including cancer require a properly orchestrated cell cycle, as well as error-free genome …
including cancer require a properly orchestrated cell cycle, as well as error-free genome …
[HTML][HTML] ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism
V Tassinari, V Cesarini, S Tomaselli, Z Ianniello… - Genome biology, 2021 - Springer
Background N 6 -methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA editing are
two of the most abundant RNA modification events affecting adenosines in mammals. Both …
two of the most abundant RNA modification events affecting adenosines in mammals. Both …
The viral load of Epstein–Barr virus (EBV) DNA in peripheral blood predicts for biological and clinical characteristics in Hodgkin lymphoma
Purpose: The Epstein–Barr virus (EBV) is present in the malignant Hodgkin/Reed–Sternberg
(HRS) cells of 20% to 40% cases of Hodgkin lymphoma (HL) in Western countries. We …
(HRS) cells of 20% to 40% cases of Hodgkin lymphoma (HL) in Western countries. We …
ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion
V Cesarini, DA Silvestris, V Tassinari… - Nucleic acids …, 2018 - academic.oup.com
Recent studies have reported the emerging role of microRNAs (miRNAs) in human cancers.
We systematically characterized miRNA expression and editing in the human brain, which …
We systematically characterized miRNA expression and editing in the human brain, which …
[HTML][HTML] ADAR-mediated RNA editing of DNA: RNA hybrids is required for DNA double strand break repair
…, S Jimeno-González, S Barroso, V Cesarini… - Nature …, 2021 - nature.com
The maintenance of genomic stability requires the coordination of multiple cellular tasks upon
the appearance of DNA lesions. RNA editing, the post-transcriptional sequence alteration …
the appearance of DNA lesions. RNA editing, the post-transcriptional sequence alteration …
Impact of age and gender on glioblastoma onset, progression, and management
A Colopi, S Fuda, S Santi, A Onorato, V Cesarini… - Mechanisms of ageing …, 2023 - Elsevier
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its
frequency in pediatric patients is 10–15%. For this reason, age is considered one of the major …
frequency in pediatric patients is 10–15%. For this reason, age is considered one of the major …
[HTML][HTML] Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma
Background Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional
mechanism mediated by ADAR enzymes that have been recently associated with cancer. …
mechanism mediated by ADAR enzymes that have been recently associated with cancer. …
[HTML][HTML] Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology
J Tiberi, V Cesarini, R Stefanelli, S Canterini… - Mechanisms of ageing …, 2023 - Elsevier
Reactive oxygen species (ROS) is a term that defines a group of unstable compounds derived
from exogenous sources or endogenous metabolism. Under physiological conditions, low …
from exogenous sources or endogenous metabolism. Under physiological conditions, low …
Epigenetic silencing of Id4 identifies a glioblastoma subgroup with a better prognosis as a consequence of an inhibition of angiogenesis
M Martini, T Cenci, GQ D'Alessandris, V Cesarini… - Cancer, 2013 - Wiley Online Library
BACKGROUND: Inhibitors of DNA binding/differentiation (Id1 to Id4) are a family of helix‐loop‐helix
transcription factors, which are highly expressed during embryogenesis and at lower …
transcription factors, which are highly expressed during embryogenesis and at lower …
[HTML][HTML] Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases
…, G Sconocchia, S Dolci, V Cesarini - Mechanisms of ageing …, 2023 - Elsevier
Aging is a physiological and progressive phenomenon in all organisms' life cycle, characterized
by the accumulation of degenerative processes triggered by several alterations within …
by the accumulation of degenerative processes triggered by several alterations within …