In mammalian skin, multiple types of resident cells are required to create a functional tissue
and support tissue homeostasis and regeneration. The cells that compose the epithelial stem …

INTRODUCTION Fibroblasts produce extracellular matrix (ECM) molecules that regulate
tissue strength and resilience. Imbalanced ECM maintenance leads to tissue dysfunction. …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Most epithelial tissues self-renew throughout adult life due to the presence of multipotent
stem cells and/or unipotent progenitor cells. Epithelial stem cells are specified during …

Skeletal muscle formation and growth require the fusion of myoblasts to form multinucleated
myofibers or myotubes, but few molecules are known to regulate myoblast fusion in …

Quiescent adult stem cells reside in specialized niches where they become activated to
proliferate and differentiate during tissue homeostasis and injury. How stem cell quiescence is …

Epidermal lineage commitment occurs when multipotent stem cells are specified to three
lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a …

The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors
whose activation is controlled by calcineurin, a Ca 2+ -dependent phosphatase. Originally …

Adipose tissue depots can exist in close association with other organs, where they assume
diverse, often non-traditional functions. In stem cell-rich skin, bone marrow, and mammary …

The mechanisms of blood vessel maturation into distinct parts of the blood vasculature such
as arteries, veins, and capillaries have been the subject of intense investigation over recent …