During 1994‐95, a small team of researchers at the Scottish Council for Research in Education
(SCRE) undertook a commissioned study of adults’ perceptions of their lifestyle options …

The earliest cell fate decision in the mammalian embryo separates the extra-embryonic
trophoblast lineage, which forms the fetal portion of the placenta, from the embryonic cell …

Importance There are currently no proven treatments to reduce the risk of mild cognitive
impairment and dementia. Objective To evaluate the effect of intensive blood pressure control on …

MBD2 and MBD3 are closely related proteins with consensus methyl-CpG binding domains.
MBD2 is a transcriptional repressor that specifically binds to methylated DNA and is a …

Heparan sulfate proteoglycans have been implicated in the presentation of a number of
secreted signaling molecules to their signal-transducing receptors. We have characterized a …

Background Cognitive ageing is a major burden for society and a major influence in lowering
people's independence and quality of life. It is the most feared aspect of ageing. There are …

Cells of early mammalian embryos have the potential to develop into any adult cell type, and
are thus said to be pluripotent. Pluripotency is lost during embryogenesis as cells commit to …

“We’re all in this together” has become a rallying cry during the coronavirus pandemic. While
it is true that COVID-19 has affected everyone in some way, the magnitude and nature of …

Clonal lineage information is fundamental in revealing cell fate choices. Using genetic
single-cell labeling in utero, we investigated lineage segregations during anteroposterior axis …

In a gene trap screen we recovered a mouse mutant line in which an insertion generated a
null allele of the Brd4 gene. Brd4 belongs to the Fsh/Brd family, a group of structurally related …