Dravet syndrome (DS) is a severe epileptic encephalopathy caused mainly by heterozygous
loss-of-function mutations of the SCN1A gene, indicating haploinsufficiency as the …

P23H is the most common mutation in the RHODOPSIN (RHO) gene leading to a dominant
form of retinitis pigmentosa (RP), a rod photoreceptor degeneration that invariably causes …

The lack of technology for direct global-scale targeting of the adult mouse nervous system
has hindered research on brain processing and dysfunctions. Currently, gene transfer is …

The visual system is one of the most accessible routes to study the central nervous system
under pathological conditions, such as in multiple sclerosis (MS). Non-invasive visual evoked …

Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder caused by mutation in
either Tsc1 or Tsc2 genes that leads to the hyper activation of the mTOR pathway, a key …

Specific and effective preventive treatment for diabetic retinopathy (DR) is presently unavailable,
mostly because the early stages of the complication have been, until recently, poorly …

Nerve growth factor (NGF) is suggested to be neuroprotective after nerve injury; however,
retinal ganglion cells (RGC) degenerate following optic-nerve crush (ONC), even in the …

Rac GTPases regulate the development of cortical/hippocampal GABAergic interneurons by
affecting the early development and migration of GABAergic precursors. We have …

Wolfram syndrome 1 (WS1) is a rare genetic disorder caused by mutations in the WFS1 gene
leading to a wide spectrum of clinical dysfunctions, among which blindness, diabetes, and …

Experimental autoimmune encephalomyelitis (EAE) is the primary disease model of multiple
sclerosis (MS), one of the most diffused neurological diseases characterized by fatigue, …