Background The spread of antibiotic-resistant bacteria poses a substantial threat to morbidity
and mortality worldwide. Due to its large public health and societal implications, multidrug-…

Background Cryptococcal meningitis associated with human immunodeficiency virus (HIV)
infection causes more than 600,000 deaths each year worldwide. Treatment has changed …

Background The irrational overuse of antibiotics should be minimized as it drives the
development of antibiotic resistance, but changing these practices is challenging. A better …

Background Community-acquired pneumonia (CAP) is a major cause of adult mortality in
Asia. Appropriate empirical treatment depends on knowledge of the pathogens commonly …

Background Talaromyces marneffei infection is a major cause of human immunodeficiency
virus (HIV)–related death in South and Southeast Asia. Guidelines recommend initial …

Background Treatment with combined sofosbuvir and velpatasvir has resulted in high
sustained virological response rates in patients chronically infected with hepatitis C virus (HCV) …

Background. Influenza A(H7N9) viruses isolated from humans show features suggesting partial
adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection…

Background It is unclear why the severity of influenza varies in healthy adults or why the
burden of severe influenza shifts to young adults when pandemic strains emerge. One …

Influenza A virus (IAV) infection represents a global threat causing seasonal outbreaks and
pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus …

Klebsiella pneumoniae clonal group (CG) 258, comprising sequence types (STs) 258, 11,
and closely related variants, is associated with dissemination of the K. pneumoniae …