BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer
disease risk factor. Here, we investigate BIN1 function in the brain using conditional knockout (…

Higher order thalamic neurons receive driving inputs from cortical layer 5 and project back
to the cortex, reflecting a transthalamic route for corticocortical communication. To determine …

Neurons in the thalamic reticular nucleus (TRN) are a primary source of inhibition to the dorsal
thalamus and, as they are innervated in part by the cortex, are a means of corticothalamic …

Streptococcus mutans is prominently linked to dental caries. Saliva's influence on caries is
incompletely understood. Our goal was to identify a salivary protein with anti- S. mutans …

Cell-free extracts isolated from colony biofilms of Actinobacillus pleuropneumoniae serotype
5 were found to inhibit biofilm formation by Staphylococcus aureus, S. epidermidis and …

The organization and cellular composition of tissues are key determinants of their biological
function. In the mammalian gastrointestinal (GI) tract, the enteric nervous system (ENS) …

Neural microarchitecture is heterogeneous, varying both across and within brain regions.
The consistent identification of regions of interest is one of the most critical aspects in …

Mammalian neurons operate at length scales spanning six orders of magnitude; they
project millimeters to centimeters across brain regions, are composed of micrometer-scale-…

Resolution level and reconstruction quality in nano-computed tomography (nano-CT) are in
part limited by the stability of microscopes, because the magnitude of mechanical vibrations …

The neotenous, or delayed, development of primate neurons, particularly human ones, is
thought to underlie primate-specific abilities like cognition. We tested whether synaptic …