Populations of tumour cells display remarkable variability in almost every discernable
phenotypic trait, including clinically important phenotypes such as ability to seed metastases and …

Intratumor heterogeneity represents a major obstacle to effective cancer treatment and
personalized medicine. However, investigators are now elucidating intratumor heterogeneity at …

Since the discovery of leptin, the adipocyte and its products have been the subject of
intensive research. Thus, it has been demonstrated that adipose tissue plays a central role in …

Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display
variable sensitivity to therapeutics and may play different roles in progression. We previously …

Cancers arise through a process of somatic evolution that can result in substantial sub-clonal
heterogeneity within tumours. The mechanisms responsible for the coexistence of distinct …

The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast,
and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, …

Cancer therapy exerts a strong selection pressure that shapes tumor evolution, yet our
knowledge of how tumors change during treatment is limited. Here, we report the analysis of …

Metastatic disease is the main cause of cancer-related mortality due to almost universal
therapeutic resistance. Despite its high clinical relevance, our knowledge of how cancer cell …

In cancer cachexia both cardiac and skeletal muscle suffer an important protein mobilization
as a result of increased proteolysis. Administration of the β 2 -agonist formoterol to both rats …

Recurrent mutations in histone-modifying enzymes imply key roles in tumorigenesis, yet their
functional relevance is largely unknown. Here, we show that JARID1B, encoding a histone …