[HTML][HTML] HHV-6A/B integration and the pathogenesis associated with the reactivation of chromosomally integrated HHV-6A/B

V Collin, L Flamand - Viruses, 2017 - mdpi.com
Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can
lead to integration of the viral genome in human chromosomes. When integration occurs in …

Cell culture systems to study human herpesvirus 6A/B chromosomal integration

…, N Wallaschek, S Gilbert-Girard, V Collin… - Journal of …, 2017 - Am Soc Microbiol
Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres
of human chromosomes. The viral and cellular factors contributing to HHV-6A/B integration …

[HTML][HTML] The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its …

V Collin, A Gravel, BB Kaufer, L Flamand - PLoS Pathogens, 2020 - journals.plos.org
Human herpesvirus 6B (HHV-6B) is a betaherpesvirus capable of integrating its genome into
the telomeres of host chromosomes. Until now, the cellular and/or viral proteins facilitating …

[HTML][HTML] Optical Genome Mapping Reveals the Complex Genetic Landscape of Myeloma

A Giguère, I Raymond-Bouchard, V Collin, JS Claveau… - Cancers, 2023 - mdpi.com
Simple Summary Myeloma is a hematological cancer characterized by numerous genetic
abnormalities currently identified using fluorescent in situ hybridization (FISH). However, FISH …

Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins

…, A Gravel, I Dubuc, N Wallaschek, V Collin… - Nucleic acids …, 2015 - academic.oup.com
Human herpesvirus-6A (HHV-6A) and HHV-6B integrate their genomes into the telomeres
of human chromosomes, however, the mechanisms leading to integration remain unknown. …

[HTML][HTML] Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration

S Gilbert-Girard, A Gravel, V Collin, DJ Wight… - PLoS …, 2020 - journals.plos.org
Human herpesviruses 6A and 6B (HHV-6A/B) are unique among human herpesviruses in
their ability to integrate their genome into host chromosomes. Viral integration occurs at the …

The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling

V Collin, É Biquand, V Tremblay, ÉG Lavoie… - EMBO …, 2024 - embopress.org
Viral infection often trigger an ATM serine/threonine kinase (ATM)-dependent DNA damage
response in host cells that suppresses viral replication. Viruses evolved different strategies …

Role of PML-nuclear bodies in human herpesvirus 6A and 6B genome integration

V Collin, A Gravel, BB Kaufer, L Flamand - bioRxiv, 2018 - biorxiv.org
Human herpesviruses 6A and 6B (HHV-6A/B) are two betaherpesviruses that readily integrate
their genomes into the telomeres of human chromosomes. To date, the cellular or viral …

The immediate early protein 1 of human herpesvirus 6B counteracts ATM activation in an NBS1-dependent manner

V Collin, É Biquand, V Tremblay, ÉG Lavoie, J Dessapt… - bioRxiv, 2021 - biorxiv.org
Viral infection often trigger an ATM-dependent DNA damage response (DDR) in host cells
that suppresses viral replication. To counteract this antiviral surveillance system, viruses …

The importance of telomeres in human herpesvirus-6A/B infections

V Collin, L Flamand - Medecine Sciences: M/S, 2022 - europepmc.org
Herpesviruses are undisputed masters of disguise. The ability to become invisible to the
immune system effectors is a complex process resting on a variety of stealth approaches. …