User profiles for Vanessa Linke

Vanessa Linke

Postdoctoral Fellow, IMol Polish Academy of Sciences
Verified email at imol.institute
Cited by 860

A large-scale genome–lipid association map guides lipid identification

V Linke, KA Overmyer, IJ Miller, DR Brademan… - Nature …, 2020 - nature.com
Despite the crucial roles of lipids in metabolism, we are still at the early stages of comprehensively
annotating lipid species and their genetic basis. Mass spectrometry–based discovery …

Defining mitochondrial protein functions through deep multiomic profiling

…, J Raiman, A Jochem, PD Hutchins, SR Peters, V Linke… - Nature, 2022 - nature.com
Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts
in recent decades have established the core protein componentry of these organelles 1 and …

[PDF][PDF] Large-scale multi-omic analysis of COVID-19 severity

…, B Paulson, DR Brademan, Y Zhu, LR Serrano, V Linke… - Cell systems, 2021 - cell.com
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …

[HTML][HTML] Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut

Q Zhang, V Linke, KA Overmyer, LL Traeger… - Nature …, 2023 - nature.com
The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied systems …

[HTML][HTML] Genetic determinants of gut microbiota composition and bile acid profiles in mice

JH Kemis, V Linke, KL Barrett, FJ Boehm… - PLoS …, 2019 - journals.plos.org
The microbial communities that inhabit the distal gut of humans and other mammals exhibit
large inter-individual variation. While host genetics is a known factor that influences gut …

Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing

…, M Rohnke, A Henß, K Peppler, V Linke… - Biomaterials, 2018 - Elsevier
The purpose of this work was to investigate new bone formation in macroporous iron foams
coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) …

[HTML][HTML] Altered microglia and neurovasculature in the Alzheimer's disease cerebellum

MK Singh-Bains, V Linke, MDR Austria, AYS Tan… - Neurobiology of …, 2019 - Elsevier
Traditionally regarded to coordinate movement, the cerebellum also exerts non-motor functions
including the regulation of cognitive and behavioral processing, suggesting a potential …

[PDF][PDF] An isoprene lipid-binding protein promotes eukaryotic coenzyme Q biosynthesis

…, D Aydin, HC Von Bank, RW Smith, V Linke… - Molecular cell, 2019 - cell.com
The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic
barriers in lipid biology. In eukaryotes, CoQ precursors—among nature's most hydrophobic …

Multi-omic single-shot technology for integrated proteome and lipidome analysis

Y He, EH Rashan, V Linke, E Shishkova… - Analytical …, 2021 - ACS Publications
Mass spectrometry (MS) serves as the centerpiece technology for proteome, lipidome, and
metabolome analysis. To gain a better understanding of the multifaceted networks of myriad …

OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization

…, D Malinska, M Borrero, BHM Mussulini, V Linke… - Journal of Cell …, 2024 - rupress.org
Most mitochondrial proteins originate from the cytosol and require transport into the organelle.
Such precursor proteins must be unfolded to pass through translocation channels in …