User profiles for Vanessa Linke
Vanessa LinkePostdoctoral Fellow, IMol Polish Academy of Sciences Verified email at imol.institute Cited by 860 |
A large-scale genome–lipid association map guides lipid identification
Despite the crucial roles of lipids in metabolism, we are still at the early stages of comprehensively
annotating lipid species and their genetic basis. Mass spectrometry–based discovery …
annotating lipid species and their genetic basis. Mass spectrometry–based discovery …
Defining mitochondrial protein functions through deep multiomic profiling
…, J Raiman, A Jochem, PD Hutchins, SR Peters, V Linke… - Nature, 2022 - nature.com
Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts
in recent decades have established the core protein componentry of these organelles 1 and …
in recent decades have established the core protein componentry of these organelles 1 and …
[PDF][PDF] Large-scale multi-omic analysis of COVID-19 severity
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
[HTML][HTML] Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut
The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied systems …
largely unknown. Here we used a genetically diverse mouse population and applied systems …
[HTML][HTML] Genetic determinants of gut microbiota composition and bile acid profiles in mice
The microbial communities that inhabit the distal gut of humans and other mammals exhibit
large inter-individual variation. While host genetics is a known factor that influences gut …
large inter-individual variation. While host genetics is a known factor that influences gut …
Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing
The purpose of this work was to investigate new bone formation in macroporous iron foams
coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) …
coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) …
[HTML][HTML] Altered microglia and neurovasculature in the Alzheimer's disease cerebellum
MK Singh-Bains, V Linke, MDR Austria, AYS Tan… - Neurobiology of …, 2019 - Elsevier
Traditionally regarded to coordinate movement, the cerebellum also exerts non-motor functions
including the regulation of cognitive and behavioral processing, suggesting a potential …
including the regulation of cognitive and behavioral processing, suggesting a potential …
[PDF][PDF] An isoprene lipid-binding protein promotes eukaryotic coenzyme Q biosynthesis
The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic
barriers in lipid biology. In eukaryotes, CoQ precursors—among nature's most hydrophobic …
barriers in lipid biology. In eukaryotes, CoQ precursors—among nature's most hydrophobic …
Multi-omic single-shot technology for integrated proteome and lipidome analysis
Mass spectrometry (MS) serves as the centerpiece technology for proteome, lipidome, and
metabolome analysis. To gain a better understanding of the multifaceted networks of myriad …
metabolome analysis. To gain a better understanding of the multifaceted networks of myriad …
OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization
…, D Malinska, M Borrero, BHM Mussulini, V Linke… - Journal of Cell …, 2024 - rupress.org
Most mitochondrial proteins originate from the cytosol and require transport into the organelle.
Such precursor proteins must be unfolded to pass through translocation channels in …
Such precursor proteins must be unfolded to pass through translocation channels in …