Purpose Studies indicate that castration-resistant prostate cancer (CRPC) remains driven by
ligand-dependent androgen receptor (AR) signaling. To evaluate this, a trial of abiraterone …

We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide
heat shock protein 90 (HSP90) inhibitor. NVP-AUY922 potently inhibits HSP90 (K d = 1.7 …

Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as
potential chemotherapeutic agents for cancer. Here, we describe the structure-based design, …

Purpose Abiraterone acetate is a prodrug of abiraterone, a selective inhibitor of CYP17, the
enzyme catalyst for two essential steps in androgen biosynthesis. In castration-resistant …

In this work 13X zeolite binderless beads were tested as a new promising material for
polymer-grade olefin production from olefin/paraffin mixtures by VPSA technology. In order to …

Inhibitor of apoptosis proteins (IAPs) are important regulators of apoptosis and pro-survival
signaling pathways whose deregulation is often associated with tumor genesis and tumor …

The search for novel and more economical ways to separate olefins and paraffins by adsorptive
processes has motivated the appearance of improved materials. Recently, metal organic …

Lead optimization studies using 7 as the starting point led to a new class of imidazo[4,5-b]pyridine-based
inhibitors of Aurora kinases that possessed the 1-benzylpiperazinyl motif at the …

Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases
including AKT, p70S6 kinase, PKA, SGK and Rho kinase is a key driver of multiple cancers…

We study the adsorption equilibrium isotherms and differential heats of adsorption of hexane
isomers on the zeolitic imidazolate framework ZIF-8. The studies are carried out at 373 K …