[PDF][PDF] SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…
Single-cell analyses of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn's disease
Background & Aims Studies are needed to determine the mechanisms of mucosal dysregulation
in patients with inflammatory bowel diseases (IBDs) and differences in inflammatory …
in patients with inflammatory bowel diseases (IBDs) and differences in inflammatory …
[HTML][HTML] Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
…, RP King, MD Mana, S Huang, V Mitsialis… - Nature …, 2021 - nature.com
A cell’s phenotype and function are influenced by dynamic interactions with its
microenvironment. To examine cellular spatiotemporal activity, we developed SPACECAT—Spatially …
microenvironment. To examine cellular spatiotemporal activity, we developed SPACECAT—Spatially …
Clinical phenotypes and outcomes in monogenic versus non-monogenic very early onset inflammatory bowel disease
…, AM Muise, C Klein, V Mitsialis… - Journal of Crohn's …, 2022 - academic.oup.com
Background and Aims Over 80 monogenic causes of very early onset inflammatory bowel
disease [VEOIBD] have been identified. Prior reports of the natural history of VEOIBD have not …
disease [VEOIBD] have been identified. Prior reports of the natural history of VEOIBD have not …
High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal …
L Konnikova, G Boschetti, A Rahman, V Mitsialis… - Mucosal …, 2018 - nature.com
Simultaneous analyses of peripheral and mucosal immune compartments can yield insight
into the pathogenesis of mucosal-associated diseases. Although methods to preserve …
into the pathogenesis of mucosal-associated diseases. Although methods to preserve …
CARMIL2 deficiency presenting as very early onset inflammatory bowel disease
Background Children with very early onset inflammatory bowel diseases (VEO-IBD) often
have a refractory and severe disease course. A significant number of described VEO-IBD-…
have a refractory and severe disease course. A significant number of described VEO-IBD-…
[HTML][HTML] Low-dose interleukin-2 ameliorates colitis in a preclinical humanized mouse model
…, M Kowalik, K Peng, J Gringauz, V Mitsialis… - Cellular and …, 2019 - cmghjournal.org
Inflammatory bowel disease (IBD) is associated with immune dysregulation triggered by
environmental factors, microbial dysbiosis, and genetical susceptibility. Regulatory T cells (Tregs…
environmental factors, microbial dysbiosis, and genetical susceptibility. Regulatory T cells (Tregs…
A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant
…, C Gonzaga-Jauregui, M Steinberg, V Mitsialis… - Journal of Clinical …, 2019 - Springer
Purpose This study aimed to characterize the clinical phenotype, genetic basis, and consequent
immunological phenotype of a boy with severe infantile-onset colitis and eosinophilic …
immunological phenotype of a boy with severe infantile-onset colitis and eosinophilic …
An RTEL1 Mutation Links to Infantile-Onset Ulcerative Colitis and Severe Immunodeficiency
Purpose More than 50 different monogenic disorders causing inflammatory bowel disease (IBD)
have been identified. Our goal was to characterize the clinical phenotype, genetic …
have been identified. Our goal was to characterize the clinical phenotype, genetic …
Efficacy and safety of anti-tumor necrosis factor alpha in very early onset inflammatory bowel disease
LV Collen, V Mitsialis, DY Kim… - Inflammatory Bowel …, 2023 - academic.oup.com
Background Very early onset inflammatory bowel disease (VEOIBD) is defined as disease
onset in patients younger than 6 years. Challenges in treatment of VEOIBD include lack of …
onset in patients younger than 6 years. Challenges in treatment of VEOIBD include lack of …