The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size
L Planas-Paz, V Orsini, L Boulter, D Calabrese… - Nature cell …, 2016 - nature.com
LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and
promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the liver…
promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the liver…
[PDF][PDF] YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors
The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue development,
regeneration, and tumorigenesis. However, its role in cholangiocarcinoma (CC) is not …
regeneration, and tumorigenesis. However, its role in cholangiocarcinoma (CC) is not …
[PDF][PDF] YAP, but not RSPO-LGR4/5, signaling in biliary epithelial cells promotes a ductular reaction in response to liver injury
…, T Sun, M Pikiolek, NR Cochran, S Bergling, V Orsini… - Cell stem cell, 2019 - cell.com
Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …
[PDF][PDF] AXIN2+ pericentral hepatocytes have limited contributions to liver homeostasis and regeneration
T Sun, M Pikiolek, V Orsini, S Bergling, S Holwerda… - Cell stem cell, 2020 - cell.com
The existence of specialized liver stem cell populations, including AXIN2 + pericentral
hepatocytes, that safeguard homeostasis and repair has been controversial. Here, using AXIN2 …
hepatocytes, that safeguard homeostasis and repair has been controversial. Here, using AXIN2 …
[PDF][PDF] Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis
R Ungricht, L Guibbal, MC Lasbennes, V Orsini… - Cell Stem Cell, 2022 - cell.com
Human organoids allow the study of proliferation, lineage specification, and 3D tissue
development. Here we present a genome-wide CRISPR screen in induced pluripotent stem cell (…
development. Here we present a genome-wide CRISPR screen in induced pluripotent stem cell (…
[PDF][PDF] ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation
T Sun, S Annunziato, S Bergling, C Sheng, V Orsini… - Cell Stem Cell, 2021 - cell.com
AXIN2 and LGR5 mark intestinal stem cells (ISCs) that require WNT/β-Catenin signaling for
constant homeostatic proliferation. In contrast, AXIN2/LGR5+ pericentral hepatocytes show …
constant homeostatic proliferation. In contrast, AXIN2/LGR5+ pericentral hepatocytes show …
[HTML][HTML] Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice
B Kinzel, M Pikiolek, V Orsini, J Sprunger, A Isken… - Developmental …, 2014 - Elsevier
Lgr4 and Lgr5 are known markers of adult and embryonic tissue stem cells in various organs.
However, whether Lgr4 and Lgr5 are important for embryonic development remains …
However, whether Lgr4 and Lgr5 are important for embryonic development remains …
[HTML][HTML] Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites
The Hippo/YAP pathway controls cell proliferation through sensing physical and spatial
organization of cells. How cell-cell contact is sensed by Hippo signaling is poorly understood. …
organization of cells. How cell-cell contact is sensed by Hippo signaling is poorly understood. …
[HTML][HTML] Loss of hepatic leucine-rich repeat-containing G-protein coupled receptors 4 and 5 promotes nonalcoholic fatty liver disease
E Saponara, C Penno, V Orsini, ZY Wang… - The American Journal of …, 2023 - Elsevier
The roof plate-specific spondin–leucine-rich repeat-containing G-protein coupled receptor 4/5
(LGR4/5)–zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a …
(LGR4/5)–zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a …
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
K Namoto, C Baader, V Orsini, A Landshammer… - Cell Stem Cell, 2024 - cell.com
The YAP/Hippo pathway is an organ growth and size regulation rheostat safeguarding multiple
tissue stem cell compartments. LATS kinases phosphorylate and thereby inactivate YAP, …
tissue stem cell compartments. LATS kinases phosphorylate and thereby inactivate YAP, …