10.7554/eLife.34408.001 Results from genome-wide association studies (GWAS) can be
used to infer causal relationships between phenotypes, using a strategy known as 2-sample …

Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic
inflammation and is known to exacerbate progression of neurodegenerative disease. To gain …

Background Fascin-1 is an actin-bundling protein expressed in many human carcinomas,
although absent from most normal epithelia. Fascin-1 promotes filopodia formation, migration …

Background Epidemiological studies have reported conflicting findings on the potential adverse
effects of long-term antihypertensive medication use on cancer risk. Naturally occurring …

Purpose To establish whether the association between milk intake and prostate cancer operates
via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2…

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder primarily affecting
motor neurons. Mutations in optineurin cause a small proportion of familial ALS cases, and …

Background Endometrial cancer is the most common gynaecological cancer in high-income
countries. Elevated body mass index (BMI) is an established modifiable risk factor for this …

This research explored parents’ perceptions of the psychosocial outcomes of their children’s
experience of receiving equine-assisted interventions (EAI). Participants were the parents …

The objective of this article is to investigate the potential role of mobile phones as a reservoir
for bacterial colonization and the risk factors for bacterial colonization in a hospital setting. …

Sleep has a regulatory role in maintaining metabolic homeostasis and cellular functions.
Inadequate sleep time and sleep disorders have become more prevalent in the modern lifestyle…