DNA methylation profiling of human chromosomes 6, 20 and 22
F Eckhardt, J Lewin, R Cortese, VK Rakyan, J Attwood… - Nature …, 2006 - nature.com
DNA methylation is the most stable type of epigenetic modification modulating the transcriptional
plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report high-…
plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report high-…
Epigenome-wide association studies for common human diseases
VK Rakyan, TA Down, DJ Balding, S Beck - Nature Reviews Genetics, 2011 - nature.com
Despite the success of genome-wide association studies (GWASs) in identifying loci associated
with common diseases, a substantial proportion of the causality remains unexplained. …
with common diseases, a substantial proportion of the causality remains unexplained. …
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
VK Rakyan, TA Down, S Maslau, T Andrew… - Genome …, 2010 - genome.cshlp.org
There is a growing realization that some aging-associated phenotypes/diseases have an
epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during …
epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during …
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis
DNA methylation is an indispensible epigenetic modification required for regulating the
expression of mammalian genomes. Immunoprecipitation-based methods for DNA methylome …
expression of mammalian genomes. Immunoprecipitation-based methods for DNA methylome …
Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission
Phenotypic variation that cannot be explained by genetic or environmental heterogeneity
has intrigued geneticists for decades. The molecular basis of this phenomenon, however, is …
has intrigued geneticists for decades. The molecular basis of this phenomenon, however, is …
[HTML][HTML] DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
Metastable epialleles in mammals
VK Rakyan, ME Blewitt, R Druker, JI Preis, E Whitelaw - Trends in Genetics, 2002 - cell.com
There are some mammalian alleles that display the unusual characteristic of variable
expressivity in the absence of genetic heterogeneity. It has recently become evident that this is …
expressivity in the absence of genetic heterogeneity. It has recently become evident that this is …
[HTML][HTML] DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project
VK Rakyan, T Hildmann, KL Novik, J Lewin, J Tost… - PLoS …, 2004 - journals.plos.org
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA
methylation phenomena. Occurring naturally on cytosine bases at cytosine–guanine …
methylation phenomena. Occurring naturally on cytosine bases at cytosine–guanine …
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)
We report a novel resource (methylation profiles of DNA, or mPod) for human genome-wide
tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts, …
tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts, …
[HTML][HTML] Identification of type 1 diabetes–associated DNA methylation variable positions that precede disease diagnosis
VK Rakyan, H Beyan, TA Down, MI Hawa… - PLoS …, 2011 - journals.plos.org
Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%,
implicating roles for genetic and non-genetic factors in the aetiology of this complex …
implicating roles for genetic and non-genetic factors in the aetiology of this complex …