Global spread and limited genetic variation are hallmarks of M. tuberculosis, the agent of
human tuberculosis. In contrast, Mycobacterium canettii and related tubercle bacilli that also …

High-throughput CRISPR-Cas9 screens have recently emerged as powerful tools to decipher
gene functions and genetic interactions. Here we use a genome-wide library of guide …

The intestinal microbiota and human health are intimately linked, but interactions between
bacteria and bacteriophages in the context of the mammalian intestine remain largely …

Horizontal gene transfer (HGT) is a major driving force of bacterial diversification and
evolution. For tuberculosis-causing mycobacteria, the impact of HGT in the emergence and …

Background The current approach to screen for drug-like molecules is to sieve for molecules
with biochemical properties suitable for desirable pharmacokinetics and reduced toxicity, …

Mycobacterium tuberculosis (Mtb) strains are classified into different phylogenetic lineages (L),
three of which (L2/L3/L4) emerged from a common progenitor after the loss of the MmpS6/…

Available chemotherapeutic options are very limited against Mycobacterium abscessus , which
imparts a particular challenge in the treatment of cystic fibrosis (CF) patients infected with …

Objectives Amongst the highly diverse Escherichia coli population, the ST131-O25b:H4
clonal complex is particularly worrisome as it is associated with a high level of antibiotic …

Trinucleotide repeat expansions are responsible for more than two dozens severe neurological
disorders in humans. A double-strand break between two short CAG/CTG trinucleotide …

The Ski2‐Ski3‐Ski8 ( SKI ) complex assists the RNA exosome during the 3′ to 5′ degradation
of cytoplasmic transcripts. Previous reports showed that the SKI complex is involved in …