M pro , the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
is essential for the viral life cycle. Accordingly, several groups have performed in silico …

Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA,
which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we …

Chromatin licensing and DNA replication factor 1 (CDT1), a protein of the pre‐replicative
complex, is essential for loading the minichromosome maintenance complex (MCM) helicases …

An important advance in cancer therapy has been the development of poly (ADP-ribose)
polymerase (PARP) inhibitors for the treatment of homologous recombination (HR)-deficient …

The most prevalent single-nucleotide substitution (SNS) found in cancers is a C-to-T
substitution in the CpG motif. It has been proposed that many of these SNSs arise during …

The Notch signaling pathway mediates cell-cell communication regulating cell differentiation
and proliferation and cell fate decisions in various tissues. In the urinary bladder, Notch acts …

The analysis of bacterial genomes is a potent tool to investigate the distribution of specific
traits related to the ability of surviving in particular environments. Among the traits associated …

Simple Summary Colorectal cancer (CRC) is one of the leading causes of cancer mortality;
it typically originates as adenomas that progress over time to carcinomas. We decided to …

The mitochondrial arm of the one-carbon pathway, which is essential for nucleotide synthesis,
becomes dominant in cancer cells due to overexpression of several enzymes of the …

M pro , also known as 3CL pro , is the main protease of the SARS-CoV-2 coronavirus and,
as such, is essential for the viral life cycle. Two studies have each screened and ranked in …