Biological insights can be obtained through computational integration of genomics data sets
consisting of diverse types of information. The integration is often hampered by a large …

In mammals, a single Dicer participates in biogenesis of small RNAs in microRNA (miRNA)
and RNAi pathways. In mice, endogenous RNAi is highly active in oocytes, but not in somatic …

Detailed knowledge of the molecular biology of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host responses, …

Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We investigated
nuclear heterogeneity and transcriptional dynamics in the uninjured and regenerating …

Protein subcellular localization is fundamental to the establishment of the body axis, cell
migration, synaptic plasticity, and a vast range of other biological processes. Protein localization …

The three-dimensional (3D) structure of chromatin is intrinsically associated with gene
regulation and cell function 1 , 2 – 3 . Methods based on chromatin conformation capture have …

The cohesin complex is crucial for chromosome segregation during mitosis and has recently
also been implicated in transcriptional regulation and chromatin architecture. The NIPBL …

Initiation of zygotic transcription in mammals is poorly understood. In mice, zygotic transcription
is first detected shortly after pronucleus formation in 1‐cell embryos, but the identity of the …

In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …

The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health threat with …