Collagen is the most abundant secreted protein in vertebrates and persists throughout life
without renewal. The permanency of collagen networks contrasts with both the continued …

Redox homeostasis and signaling are critically important in the regulation of cell function.
There are significant challenges in quantitatively measuring intracellular redox potentials, and …

Cells respond to stress by synthesizing chaperone proteins that seek to correct protein
misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of …

Studies of cellular mechano-signaling have often utilized static models that do not fully
replicate the dynamics of living tissues. Here, we examine the time-dependent response of …

Significance: Aging is a consequence of the accumulation of cellular damage that impairs the
capacity of an aging organism to adapt to stress. The Mitochondrial Free Radical Theory of …

Vertebrate tissues exhibit mechanical homeostasis, showing stable stiffness and tension over
time and recovery after changes in mechanical stress. However, the regulatory pathways …

Background Haematoxylin and eosin (H&E)—which respectively stain nuclei blue and other
cellular and stromal material pink—are routinely used for clinical diagnosis based on the …

The role of cellular redox potential in the regulation of protein activity is becoming increasingly
appreciated and characterized. In this paper we put forward a new hypothesis relating to …

Objective Cartilage in joints such as the hip and knee experiences repeated phases of heavy
loading and low load recovery during the 24-háday/night cycle. Our previous work has …

Although dysfunctional protein homeostasis (proteostasis) is a key factor in many age‐related
diseases, the untargeted identification of structurally modified proteins remains challenging…