Genetic errors in meiosis can lead to birth defects and spontaneous abortions. Checkpoint
mechanisms of hitherto unknown nature eliminate oocytes with unrepaired DNA damage, …

Feline coronaviruses (FCoV) exist as 2 biotypes: feline enteric coronavirus (FECV) and feline
infectious peritonitis virus (FIPV). FECV causes subclinical infections; FIPV causes feline …

Pairing and synapsis of homologous chromosomes during meiosis is crucial for producing
genetically normal gametes and is dependent upon repair of SPO11-induced double-strand …

Following testicular spermatogenesis, mammalian sperm continue to mature in a long epithelial
tube known as the epididymis, which plays key roles in remodeling sperm protein, lipid, …

Identifying genomic alterations driving breast cancer is complicated by tumor diversity and
genetic heterogeneity. Relevant mouse models are powerful for untangling this problem …

Unrepaired DNA damage in mouse oocytes leads to apoptosis, in part via CHK2 signaling
to TRP53 and TRP63. Here, Rinaldi, Bloom, and Schimenti provide evidence that CHK1 can …

Ovarian function is directly correlated with survival of the primordial follicle reserve. Women
diagnosed with cancer have a primary imperative of treating the cancer, but since the resting …

Canine alphacoronaviruses (CCoV) exist in two serotypes, type I and II, both of which can
cause severe gastroenteritis. Here, we characterize a canine alphacoronavirus, designated …

Beyond the haploid genome, mammalian sperm carry a payload of epigenetic information
with the potential to modulate offspring phenotypes. Recent studies show that the small RNA …

Monitoring of student learning through systematic formative assessment is important for
adjusting pedagogical strategies. However, traditional formative assessments, such as quizzes …