Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…

Epigenetic and transcriptional variability contribute to the vast diversity of cellular and
organismal phenotypes and are key in human health and disease. In this review, we describe …

Background Early reports on patients with cancer and COVID-19 have suggested a high
mortality rate compared with the general population. Patients with thoracic malignancies are …

Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias,
and susceptibility to mitochondrial inhibitors in cancer cells. Here, we first show that cell lines, …

Highlights • Networks are a useful framework to study chromatin structure datasets. • Chromatin
networks can be used to visualize the 3D epigenome and integrate datasets. • Network …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation
program by whole-genome bisulfite sequencing and high-density microarrays. We …

CD8 + T cells within the tumor microenvironment (TME) are exposed to various signals that
ultimately determine functional outcomes. Here, we examined the role of the co-activating …

Inference of gene regulatory networks has been an active area of research for around 20
years, leading to the development of sophisticated inference algorithms based on a variety of …

Background A healthy immune system requires immune cells that adapt rapidly to
environmental challenges. This phenotypic plasticity can be mediated by transcriptional and …