Unique sensitivity of tumor cells to the inhibition of glycolysis is a good target for anticancer
therapy. Here, we demonstrate that the pharmacologically activated tumor suppressor p53 …

Targeting "oncogene addiction" is a promising strategy for anticancer therapy. We report a
potent inhibition of crucial oncogenes by p53 upon reactivation by small-molecule RITA in …

Restoration of the p53 tumor suppressor for personalised cancer therapy is a promising
strategy. However, high-affinity MDM2 inhibitors have shown substantial side effects in clinical …

The MAPK/ERK pathway plays an important role in the regulation of gene expression
during memory formation both in vertebrates and invertebrates. In the mollusk Helix lucorum, …

DNA methylation is one of the main mechanisms of epigenetic inheritance in eukaryotes. In
this review we looked through the ways of 5-methylcytosin origin, it's distribution in genome, …

Reinstatement of the p53 tumor suppressor function in cancers by small molecules is a
promising strategy to combat cancer. In this chapter, we focus on the concept of targeting wild-…

Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which
mainstream treatments have not changed for decades. To identify additional therapeutic targets …

To identify approaches to target DNA repair vulnerabilities in cancer, we discovered
nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase …

Highlights Small molecule RITA binds p53 in cells and in vitro RITA interferes with p53/MDM2
and p53/MDMX interaction via allosteric mechanism RITA binds to SPLPS site and …

Given the immense significance of p53 restoration for anti-cancer therapy, elucidation of the
mechanisms of action of p53-activating molecules is of the utmost importance. Here we …