Regulatory landscapes drive complex developmental gene expression, but it remains unclear
how their integrity is maintained when incorporating novel genes and functions during …

Structural variants are a common cause of disease and contribute to a large extent to inter-individual
variability, but their detection and interpretation remain a challenge. Here, we …

Motivation Identifying target promoters of active enhancers is a crucial step for realizing gene
regulation and deciphering phenotypes and diseases. Up to now, several computational …

Cohesin loop extrusion facilitates precise gene expression by continuously driving promoters
to sample all enhancers located within the same topologically-associated domain (TAD). …

… We thank our colleagues Robert Schöpflin, Peter Holderrieth, and Verena Laupert (née
Heinrich) for providing feedback and criticism on the developing manuscript. …

Chitosan treatment results in significantly lower serum low density lipoprotein (LDL) cholesterol
concentrations. To assess the working mechanisms of chitosan, we measured serum …