Prolactin-releasing peptide (PrRP) belongs to the large RF-amide neuropeptide family with
a conserved Arg-Phe-amide motif at the C-terminus. PrRP plays a main role in the regulation …

Obesity is an escalating epidemic, but an effective noninvasive therapy is still scarce. For
obesity treatment, anorexigenic neuropeptides are promising tools, but their delivery from the …

Obesity and type 2 diabetes mellitus (T2DM) are important risk factors for Alzheimer's disease
(AD). Drugs originally developed for T2DM treatment, eg, analog of glucagon-like peptide …

Analogs of anorexigenic neuropeptides, such as prolactin-releasing peptide (PrRP), have a
potential as new anti-obesity drugs. In our previous study, palmitic acid attached to the N-…

Hydrogen to deuterium isotopic substitution has only a minor effect on physical and chemical
properties of water and, as such, is not supposed to influence its neutral taste. Here we …

The selection of a suitable matrix and deposition technique constitutes a critical step in
successful matrix-assisted laser desorption/ionization mass spectrometry imaging measurement. …

Mass spectrometry imaging (MSI) is a modern analytical technique capable of monitoring the
spatial distribution of compounds within target tissues. Collection and storage are important …

G-protein-coupled receptor GPR10 is expressed in brain areas regulating energy metabolism.
In this study, the effects of GPR10 gene deficiency on energy homeostasis in mice of both …

Background/Objectives Prolactin-releasing peptide (PrRP) has a potential to decrease food
intake and ameliorate obesity, but is ineffective after peripheral administration. We have …

Lack of leptin production in ob/ob mice results in obesity and prediabetes that could be partly
reversed by leptin supplementation. In the hypothalamus, leptin supports the production of …