In acute myeloid leukaemia, long-term survival is poor as most patients relapse despite
achieving remission 1 . Historically, the failure of therapy has been thought to be due to …

Pathway enrichment analysis helps researchers gain mechanistic insight into gene lists
generated from genome-scale (omics) experiments. This method identifies biological pathways …

Recent studies indicate that cancer-associated fibroblasts (CAFs) are phenotypically and
functionally heterogeneous. However, little is known about CAF subtypes, the roles they play in …

From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose
knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial …

Functional heterogeneity within tumors presents a significant therapeutic challenge. Here
we show that quiescent, therapy-resistant Sox2 + cells propagate sonic hedgehog subgroup …

To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC),
we generated a prognostic LSC-associated miRNA signature derived from functionally …

Many long‐lived species of animals require the function of adult stem cells throughout their
lives. However, the transcriptomes of stem cells in invertebrates and vertebrates have not …

Lifelong blood cell production is governed through the poorly understood integration of cell-intrinsic
and -extrinsic control of hematopoietic stem cell (HSC) quiescence and activation. …

The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising
therapies entering clinical translation, yet patient responses remain heterogeneous, and …

Isolation and characterization of subclones from diagnosis samples of patients with B-ALL
who relapsed showed that relapse-fated subclones had increased drug tolerance and distinct …