Pathogenesis induced by SARS-CoV-2 is thought to result from both an inflammation-dominated
cytokine response and virus-induced cell perturbation causing cell death. Here, we …

Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs),
populate inflamed or cancerous tissue and block immune cell effector functions. The lack of …

Importance School and daycare closures were enforced as measures to confine the novel
coronavirus disease 2019 (COVID-19) pandemic, based on the assumption that young …

The secretory pathway in mammalian cells has evolved to facilitate the transfer of cargo
molecules to internal and cell surface membranes. Use of automated microscopy-based genome…

10.7554/eLife.04114.001 The steps from HIV-1 cytoplasmic entry until integration of the
reverse transcribed genome are currently enigmatic. They occur in ill-defined reverse-…

10.7554/eLife.41800.001 Nuclear entry of HIV-1 replication complexes through intact
nuclear pore complexes is critical for successful infection. The host protein cleavage-and-…

Understanding of redox signaling requires data on the spatiotemporal distribution of hydrogen
peroxide (H 2 O 2 ) within the cell. The fluorescent reporter HyPer is a powerful instrument …

HIV-1 replication commences inside the cone-shaped viral capsid, but timing, localization,
and mechanism of uncoating are under debate. We adapted a strategy to visualize individual …

Malaria-causing parasites proliferate within erythrocytes through schizogony, forming
multinucleated stages before cellularization. Nuclear multiplication does not follow a strict …

T cell antigen receptor (TCR) signaling triggers selective cytokine expression to drive T cell
proliferation and differentiation required for immune defense and surveillance. The nuclear …