The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

Gene expression data are accumulating exponentially in public repositories. Reanalysis and
integration of themed collections from these studies may provide new insights, but requires …

Large-scale phenotyping efforts have demonstrated that approximately 25–30% of mouse
gene knockouts cause intrauterine lethality. Analysis of these mutants has largely focused on …

Global mechanisms defining the gene expression programs specific for hematopoiesis are
still not fully understood. Here, we show that promoter DNA demethylation is associated with …

Mammalian reproductive performance declines rapidly with advanced maternal age. This
effect is largely attributed to the exponential increase in chromosome segregation errors in the …

… The E12.5 embryo drawings are adapted from Perez-Garcia, V. et al. Placentation defects
are … This schematic is adapted from Perez-Garcia, V. et al. Placentation defects are highly …

Critical roles for DNA methylation in embryonic development are well established, but less
is known about its roles during trophoblast development, the extraembryonic lineage that …

In all eutherian mammals, growth of the fetus is dependent upon a functional placenta, but
whether and how the latter adapts to putative fetal signals is currently unknown. Here, we …

Two recently developed models, trophoblast organoids and trophoblast stem cells (TSCs),
are useful tools to further the understanding of human placental development. Both …

Here we studied and characterized different peripheral blood (PB) regulatory T cell (Treg)
subsets in rheumatoid arthritis (RA) patients and tested the hypothesis that changes in these …