Mitochondrial dysfunction increases reactive oxygen species (ROS) production and when
this overwhelms the cellular antioxidant defences, oxidative stress ensues. Oxidative stress is …

The similarities between glaucoma and mitochondrial optic neuropathies have driven a
growing interest in exploring mitochondrial function in glaucoma. The specific loss of retinal …

Purpose: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated
protein (Cas) has recently been adapted to enable efficient editing of the …

Purpose.: Following the recent demonstration of increased mitochondrial DNA mutations in
lymphocytes of POAG patients, the authors sought to characterize mitochondrial function in a …

Retinal ganglion cell (RGC) degeneration causes vision loss in patients with glaucoma, and
this has been generally considered to be irreversible due to RGC death. We question this …

Glaucoma is increasingly recognized as a neurodegenerative disorder, characterized by the
accelerated loss of retinal ganglion cells (RGCs) and their axons. Impaired axonal transport …

Purpose.: To determine the presence and magnitude of the photopic negative response (PhNR)
component of the electroretinogram (ERG) in the mouse eye and to test if it is altered by …

Retinal ganglion cells ( RGC s) become increasingly vulnerable to injury with advancing age.
We recently showed that this vulnerability can be strongly modified in mice by exercise. …

Advancing age is a major risk factor for many neurodegenerative diseases but the underlying
pathophysiology is not clear. We hypothesize that aging impairs the ability of neurons in …

We describe a model of acute intraocular pressure (IOP) elevation in the mouse eye that
induces reversible loss of inner retinal function associated with oxidative stress, glial cell …