Autosomal recessive polycystic kidney disease (ARPKD), usually considered to be a genetically
homogeneous disease caused by mutations in PKHD1, has been associated with ciliary …

Neural induction in vertebrates generates a CNS that extends the rostral-caudal length of
the body. The prevailing view is that neural cells are initially induced with anterior (forebrain) …

WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns
posterior identity in the epiblast and induces mesodermal tissue. Here we provide evidence …

The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4 + T cells
in vitro. However, the global effects of c-Maf on diverse immune responses in vivo are …

Understanding the mechanisms that control induction and elaboration of the vertebrate
central nervous system (CNS) requires an analysis of the extrinsic signals and downstream …

The development of the vertebrate body axis relies on the activity of different populations of
axial progenitors, including neuromesodermal progenitors. Currently, the term ‘…

Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it
regulates chromatin organization to coordinate the activation of neural genes is unclear. …

During development, gene regulatory networks allocate cell fates by partitioning tissues into
spatially organised domains of gene expression. How the sharp boundaries that delineate …

The vertebrate hedgehog receptor patched 1 (Ptc1) is crucial for negative regulation of the
sonic hedgehog (Shh) pathway during anterior-posterior patterning of the limb. We have …

Over the past decade, the primary cilium has emerged as a pivotal sensory organelle that
acts as a major signaling hub for a number of developmental signaling pathways. In that time, …