User profiles for Victor A. Maltsev
 | VICTOR A MALTSEVNational Institute on Aging, National Institutes of Health Verified email at grc.nia.nih.gov Cited by 10573 |
A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart's Pacemaker
EG Lakatta, VA Maltsev, TM Vinogradova - Circulation research, 2010 - Am Heart Assoc
Ion channels on the surface membrane of sinoatrial nodal pacemaker cells (SANCs) are the
proximal cause of an action potential. Each individual channel type has been thoroughly …
proximal cause of an action potential. Each individual channel type has been thoroughly …
Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types
VA Maltsev, J Rohwedel, J Hescheler… - Mechanisms of …, 1993 - Elsevier
Pluripotent embryonic stem cells (ESC, ES cells) of line D3 were differentiated in vitro via
embryo-like aggregates (embryoid bodies) of defined cell number into spontaneously beating …
embryo-like aggregates (embryoid bodies) of defined cell number into spontaneously beating …
Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.
VA Maltsev, AM Wobus, J Rohwedel, M Bader… - Circulation …, 1994 - Am Heart Assoc
Cardiomyocytes differentiated in vitro from pluripotent embryonic stem (ES) cells of line D3
via embryo-like aggregates (embryoid bodies) were characterized by the whole-cell patch-…
via embryo-like aggregates (embryoid bodies) were characterized by the whole-cell patch-…
Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes
VA Maltsev, HN Sabbah, RSD Higgins, N Silverman… - Circulation, 1998 - Am Heart Assoc
Background—Alterations in K + channel expression and gating are thought to be the major
cause of action potential remodeling in heart failure (HF). We previously reported the …
cause of action potential remodeling in heart failure (HF). We previously reported the …
Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate
…, R Wang, M Nirmalan, U Wisloff, VA Maltsev… - …, 2014 - Am Heart Assoc
Heart rate (HR) variability (HRV; beat-to-beat changes in the R-wave to R-wave interval) has
attracted considerable attention during the past 30+ years (PubMed currently lists >17 000 …
attracted considerable attention during the past 30+ years (PubMed currently lists >17 000 …
High Basal Protein Kinase A–Dependent Phosphorylation Drives Rhythmic Internal Ca2+ Store Oscillations and Spontaneous Beating of Cardiac Pacemaker Cells
…, RP Xiao, H Cheng, MD Stern, VA Maltsev… - Circulation …, 2006 - Am Heart Assoc
Local, rhythmic, subsarcolemmal Ca 2+ releases (LCRs) from the sarcoplasmic reticulum (SR)
during diastolic depolarization in sinoatrial nodal cells (SANC) occur even in the basal …
during diastolic depolarization in sinoatrial nodal cells (SANC) occur even in the basal …
Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model
VA Maltsev, EG Lakatta - American Journal of Physiology …, 2009 - journals.physiology.org
Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks
confers robust and flexible pacemaker function in a novel pacemaker cell model | American …
confers robust and flexible pacemaker function in a novel pacemaker cell model | American …
Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability
VA Maltsev, N Silverman, HN Sabbah… - European journal of …, 2007 - Wiley Online Library
Background: Late Na + current (I NaL ) in human and dog hearts has been implicated in
abnormal repolarization associated with heart failure (HF). HF slows inactivation gating of late …
abnormal repolarization associated with heart failure (HF). HF slows inactivation gating of late …
Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function
VA Maltsev, EG Lakatta - Cardiovascular research, 2008 - academic.oup.com
For almost half a century it has been thought that the initiation of each heartbeat is driven by
surface membrane voltage-gated ion channels (M clocks) within sinoatrial nodal cells. It has …
surface membrane voltage-gated ion channels (M clocks) within sinoatrial nodal cells. It has …
Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences
VA Maltsev, V Reznikov… - American Journal …, 2008 - journals.physiology.org
Augmented and slowed late Na + current (I NaL ) is implicated in action potential duration
variability, early afterdepolarizations, and abnormal Ca 2+ handling in human and canine …
variability, early afterdepolarizations, and abnormal Ca 2+ handling in human and canine …