User profiles for Victor G. Miranda
Victor G. Calvillo-MirandaChemical Biology PhD student Verified email at g.harvard.edu Cited by 185 |
[HTML][HTML] Structural insights into TDP-43 and effects of post-translational modifications
Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative
diseases. In this review, we have gathered and presented structural information on the …
diseases. In this review, we have gathered and presented structural information on the …
[HTML][HTML] An in silico method to assess antibody fragment polyreactivity
Antibodies are essential biological research tools and important therapeutic agents, but
some exhibit non-specific binding to off-target proteins and other biomolecules. Such …
some exhibit non-specific binding to off-target proteins and other biomolecules. Such …
Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)
…, DD Scott, MR Sayegh, VG Miranda… - ACS chemical …, 2019 - ACS Publications
RNA dysregulation likely contributes to disease pathogenesis of amyotrophic lateral
sclerosis (ALS) and other neurodegenerative diseases. A pathological form of the transactive …
sclerosis (ALS) and other neurodegenerative diseases. A pathological form of the transactive …
An allosteric modulator of RNA binding targeting the N-terminal domain of TDP-43 yields neuroprotective properties
…, JM Carlson, Y Dong, X Li, VG Miranda… - ACS chemical …, 2020 - ACS Publications
In this study, we targeted the N-terminal domain (NTD) of transactive response (TAR) DNA
binding protein (TDP-43), which is implicated in several neurodegenerative diseases. In silico …
binding protein (TDP-43), which is implicated in several neurodegenerative diseases. In silico …
In Silico Targeting of the Long Noncoding RNA MALAT1
L François-Moutal, VG Miranda… - ACS Medicinal …, 2021 - ACS Publications
RNA targeting has gained traction over the past decade. It has become clear that dysregulation
of RNA can be linked to many diseases, leading to a need for new scaffolds recognizing …
of RNA can be linked to many diseases, leading to a need for new scaffolds recognizing …
[PDF][PDF] Corrigendum: Structural Insights Into TDP-43 and Effects of Post-translational Modifications
…, S Perez-Miller, DD Scott, VG Miranda… - Frontiers in molecular …, 2020 - academia.edu
In the original article, there was an error. In “Binding of Zinc was shown to increase TDP-43
thermostability and formed Thioflavin-T-positive aggregates, reminiscent of amyloid nuclei (…
thermostability and formed Thioflavin-T-positive aggregates, reminiscent of amyloid nuclei (…
Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief
We have previously reported that the microtubule-associated collapsin response mediator
protein 2 (CRMP2) is necessary for the expression of chronic pain. CRMP2 achieves this …
protein 2 (CRMP2) is necessary for the expression of chronic pain. CRMP2 achieves this …
The M3 muscarinic acetylcholine receptor can signal through multiple G protein families
…, AS Hilibrand, MA Skiba, VG Calvillo-Miranda… - Molecular …, 2024 - ASPET
The M3 muscarinic acetylcholine receptor (M 3 R) is a G protein coupled receptor (GPCR)
that regulates important physiological processes including vascular tone, bronchoconstriction, …
that regulates important physiological processes including vascular tone, bronchoconstriction, …
Complete Genome Sequences of Eight Rhizobium Symbionts Associated with Common Bean (Phaseolus vulgaris)
…, F Miranda-Sánchez… - Microbiology …, 2017 - search.proquest.com
ABSTRACT We present here the high-quality complete genome sequences of eight strains
of Rhizobium-nodulating Phaseolus vulgaris. Comparative analyses showed that some of …
of Rhizobium-nodulating Phaseolus vulgaris. Comparative analyses showed that some of …
Loss of CD30 expression after treatment with brentuximab vedotin in a patient with anaplastic large cell lymphoma: a novel finding
…, P Nagarajan, JL Curry, RN Miranda… - Journal of cutaneous …, 2016 - Wiley Online Library
Anaplastic large cell lymphoma ( ALCL ) is an aggressive T‐cell lymphoma characterized
by strong and uniform expression of CD30 . Brentuximab vedotin ( BV ), an anti‐ CD30 …
by strong and uniform expression of CD30 . Brentuximab vedotin ( BV ), an anti‐ CD30 …