We sequenced 122 miRNAs in 10 primate species to reveal conservation characteristics of
miRNA genes. Strong conservation is observed in stems of miRNA hairpins and increased …

The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative
cells are confined to crypts, while differentiated cell types predominantly occupy the villi. …

The incomplete identification of structural variants (SVs) from whole-genome sequencing
data limits studies of human genetic diversity and disease association. Here, we apply a suite …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Mutations create variation in the population, fuel evolution and cause genetic diseases. Current
knowledge about de novo mutations is incomplete and mostly indirect 1 , 2 , 3 , 4 , 5 , 6 , …

A variety of mutational mechanisms shape the dynamic architecture of human genomes and
occasionally result in congenital defects and disease. Here, we used genome-wide long …

Within the Netherlands a national network of biobanks has been established (Biobanking and
Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the …

icroRNAs are 20- to 23-nucleotide RNA molecules that can regulate gene expression. Currently
>400 microRNAs have been experimentally identified in mammalian genomes, whereas …

Advancing our understanding of embryonic development is heavily dependent on
identification of novel pathways or regulators. Although genome-wide techniques such as RNA …