Bacterial infection often results in the formation of tissue abscesses, which represent the
primary site of interaction between invading bacteria and the innate immune system. We identify …

T-helper-17 (T H 17) cells have critical roles in mucosal defence and in autoimmune disease
pathogenesis 1 , 2 , 3 . They are most abundant in the small intestine lamina propria, where …

Although microbial populations in the gut microbiome are associated with COVID-19 severity,
a causal impact on patient health has not been established. Here we provide evidence …

The pathogenesis of human infections caused by the gram-positive microbe Staphylococcus
aureus has been previously shown to be reliant on the acquisition of iron from host …

Pore-forming toxins are critical virulence factors for many bacterial pathogens and are central
to Staphylococcus aureus-mediated killing of host cells. S. aureus encodes pore-forming bi…

Staphylococcus aureus is a major bacterial pathogen that causes disease worldwide. The
emergence of strains that are resistant to commonly used antibiotics and the failure of vaccine …

The ability to produce water-soluble proteins with the capacity to oligomerize and form pores
within cellular lipid bilayers is a trait conserved among nearly all forms of life, including …

Staphylococcus aureus is a formidable pathogen capable of causing infections in different
sites of the body in a variety of vertebrate animals, including humans and livestock. A major …

Recent evidence indicates that the secreted Helicobacter pylori vacuolating toxin (VacA)
inhibits the activation of T cells. VacA blocks IL-2 secretion in transformed T cell lines by …

Staphylococcus aureus is an eminent human pathogen that can colonize the human host
and cause severe life-threatening illnesses. This bacterium can reside in and infect a wide …